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題名 | Diffuse Large B Cell Lymphoma Coexistence with Systemic Mastocytosis= |
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作者 | Chien, Sheng-hsuan; Liu, Yao-chung; Hong, Ying-chung; Yang, Ching-fen; Liu, Chun-yu; Chiou, Tzeon-jye; Tzeng, Cheng-hwai; Liu, Jin-hwang; Gau, Jyh-pyng; |
期刊 | Journal of Cancer Research and Practice |
出版日期 | 20160600 |
卷期 | 3:2 2016.06[民105.06] |
頁次 | 頁45-48 |
分類號 | 415.6 |
語文 | eng |
關鍵詞 | Diffuse large B cell lymphoma; Systemic mastocytosis; Systemic mastocytosis associated with a clonal non-mast cell lineage; Tryptase; KIT mutation; |
英文摘要 | Systemic mastocytosis is a rare disease and characterized by excessive mast cell accumulation in one or multiple organs. One subtype of systemic mastocytosis is systemic mastocytosis-associated clonal hematological non-mast cell lineage disease (SM-AHMND), which indicates concurrent evolution of two separate clonal entities, one consisting of mast cells and one as a second hematological as well as nonmast cell origin disease. When SM-AHMND is diagnosed, bone marrow examination is essential for the initial approach, because marrow is almost universally involved in adult mastocytosis and it facilitates detection of a second hematological neoplasm. Myeloid neoplasm is reported to be the most prevalent associated clonal hematological non-mast cell disease. Treatment strategy and outcome for SM-AHMND is dependent on hematological non-mast cell lineage disease. Herein, we have presented a case report of diffuse large B cell lymphoma coexisting with systemic mastocytosis where the patient underwent successful chemotherapy leading to extended survival duration. |
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