頁籤選單縮合
題名 | Thymol Reduces Oxidative Stress, Aortic Intimal Thickening, and Inflammation-related Gene Expression in Hyperlipidemic Rabbits= |
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作者 | Yu, Ya-mei; Chao, Tzu-yu; Chang, Weng-cheng; Chang, Margaret J.; Lee, Ming-fen; |
期刊 | Journal of Food and Drug Analysis |
出版日期 | 20160700 |
卷期 | 24:3 2016.07[民105.07] |
頁次 | 頁556-563 |
分類號 | 414.34 |
語文 | eng |
關鍵詞 | Antioxidant; Atherosclerosis; Inflammatory markers; Oxidative stress; Thymol; |
英文摘要 | Atherosclerosis plays a key role in the development of cardiovascular diseases, and is often associated with oxidative stress and local inflammation. Thymol, a major polyphenolic compound in thyme, exhibits antioxidant and anti-inflammatory properties. In this study, we measured the in vitro antioxidant activity of thymol, and investigated the effect of thymol on high-fat-diet-induced hyperlipidemia and atherosclerosis. New Zealand white rabbits were fed with regular chow, high-fat and high-cholesterol diet (HC), T3, or T6 (HC with thymol supplementation at 3 mg/kg/d or 6 mg/kg/d, respectively) for 8 weeks. Aortic intimal thickening, serum lipid parameters, multiple inflammatory markers, proinflammatory cytokines, and atherosclerosis-associated indicators were significantly increased in the HC group but decreased upon thymol supplementation. In summary, thymol exhibits antioxidant activity, and may suppress the progression of high-fat-diet-induced hyperlipidemia and atherosclerosis by reducing aortic intimal lipid lesion, lowering serum lipids and oxidative stress, and alleviating inflammation-related responses. |
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