頁籤選單縮合
題 名 | In vitro Activity of Colistin Sulfate against Enterobacteriaceae Producing Extended-spectrum β-lactamases |
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作 者 | Ku, Yee-huang; Lee, Mei-feng; Chuang, Yin-ching; Chen, Chi-chung; Yu, Wen-liang; | 書刊名 | Journal of Microbiology, Immunology and Infection |
卷 期 | 48:6 2015.12[民104.12] |
頁 次 | 頁699-702 |
分類號 | 414.83 |
關鍵詞 | Colistin; Enterobacteriaceae; ESBL; Tigecycline; |
語 文 | 英文(English) |
英文摘要 | The widespread multidrug-resistant Enterobacteriaceae pose a serious therapeutic challenge. Colistin and tigecycline are potential antimicrobial agents for treating infections caused by extended-spectrum b-lactamase (ESBL)-producing Enterobacteriaceae.We evaluated the in-vitro activity of colistin sulfate against 253 ESBL producers isolated from patients admitted to a medical center in southern Taiwan (Escherichia coli, n Z 82; Klebsiella pneumoniae, n Z 102; Enterobacter cloacae, n Z 34; and Serratia marcescens, n Z 35). Colistin showed promising in-vitro activity against E. coli, K. pneumoniae, and E. cloacae, but not S. marcescens. One ESBL-producing K. pneumoniae strain with resistance to carbapenems (ertapenem, imipenem, and meropenem) was selected for time-killing studies. A combination of colistin and tigecycline showed synergism, but there was an inoculum effect. In conclusion, colistin was active against most ESBL-producing nterobacteriaceae, and a combination of colistin with tigecycline was synergistic against some highly resistant strains, even those with carbapenem resistance. |
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