查詢結果分析
相關文獻
頁籤選單縮合
題名 | Comparisons between Patients with Trimethoprim-sulfamethoxazole-susceptible and Trimethoprim-sulfamethoxazole-resistant Stenotrophomonas maltophilia Monomicrobial Bacteremia: A 10-year Retrospective Study= |
---|---|
作者 | Wang, Ching-hsun; Lin, Jung-chung; Lin, Hsin-an; Chang, Feng-yee; Wang, Ning-chi; Chiu, Sheng-kang; Lin, Te-yu; Yang, Ya-sung; Kan, Li-ping; Yang, Chin-hsuan; Chan, Ming-chin; Yeh, Kuo-ming; |
期刊 | Journal of Microbiology, Immunology and Infection |
出版日期 | 20160600 |
卷期 | 49:3 2016.06[民105.06] |
頁次 | 頁378-386 |
分類號 | 415.27 |
語文 | eng |
關鍵詞 | Bacteremia; Resistance; Stenotrophomonas maltophilia; Trimethoprim-sulfamethoxazole; |
英文摘要 | Background/purpose: The impact of bacteremia due to the resistance of Stenotrophomonas maltophilia to trimethoprimesulfamethoxazole (TMPeSXT) is uncertain. This study compared the clinical characteristics and outcomes of patients with TMPeSXT-susceptible (TSSSM) and TMPeSXT-resistant S. maltophilia (TSRSM) monomicrobial bacteremia. Methods: The medical records of adult patients with TSSSM and TSRSM monomicrobial bacteremia from January 2004 to December 2013 were reviewed and classified into two groups, namely, TSSSM and TSRSM. Results: There were 184 patients with monomicrobial S. maltophilia bacteremia. The mean age was 68.3 years. Most patients were males (72.8%), had high Charlson Comorbidity Index scores, previously prescribed antimicrobial agents, and indwelling medical devices. The 14- day and in-hospital mortality rates were 23.9% and 47.2%, respectively. There were 128 patients (69.6%) with TSSSM and 56 (30.4%) with TSRSM. The incidence of TSSSM bacteremia increased during the study period. The TSSSM and TSRSM groups had similar demographic and clinical characteristics and no significant differences in 14-day and in-hospital mortality (24.2% vs. 23.2%, p Z 0.833; 50.0% vs. 41.1%, p Z 0.264, respectively). Patients with TSSSM bacteremia had an increased risk of septic shock (p Z 0.044) and neutropenia (p Z 0.028) at bacteremia onset. Logistic regression analysis indicated that acquisition of TMPeSXT resistance was an independent risk factor for prolonged hospitalization (p Z 0.018) and catheter-related S. maltophilia bacteremia was inversely associated with prolonged hospitalization after bacteremia (p Z 0.032). Conclusion: There were no significant differences in mortality for patients with TSSSM and TSRSM bacteremia, but patients with TSRSM bacteremia were associated with prolonged hospitalization after bacteremia onset. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。