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題名 | The Advantage of Bevacizumab in Treating Colorectal Brain Metastasis=Bevacizumab對於結腸直腸癌合併腦轉移的治療成效 |
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作者 | 陳鴻明; 鄧豪偉; Chen, Hung-ming; Teng, Hao-wei; |
期刊 | 臺灣癌症醫學雜誌 |
出版日期 | 20140900 |
卷期 | 1:2 2014.09[民103.09] |
頁次 | 頁146-151 |
分類號 | 418.31 |
語文 | eng |
關鍵詞 | 生物化學治療; 癌思停; 結腸直腸癌; 腦轉移; Biochemotherapy; Bevacizumab; Avastin; Colorectal cancer; Brain metastasis; |
中文摘要 | Bevacizumab 是一種人工合成單株性抗體主要可抑制血管內皮細胞生長因子,目前被 廣泛運用在許多癌症,例如乳癌、結腸直腸癌,非小細胞肺癌以及高度膠質瘤等等,主 要目的在於延緩疾病的惡化,而非讓疾病獲得治癒。因為高分子量,bevacizumab 在以往 都被視無法穿透血腦屏障,然而根據一些關於其對腦瘤的療效的研究,bevacizumab 目前 被相信仍會有部分穿透血腦屏障的能力,但儘管如此由於其缺乏全盤安全性資料以及會 增加顱內出血的機率,在多年前美國食品藥物管理局已經將 bevacizumab 對於大腸直腸癌 合併腦轉移的適應症撤銷,因此目前關於其對於大腸致腸癌合併腦轉移治療相關的研究 極少。在這篇文章中,我們呈現一位結腸直腸癌合併腦轉移病患在接受 bevacizumab 合併 化學治療後腦病灶明顯縮小的案例。 |
英文摘要 | Bevacizumab is known to be a humanized monoclonal antibody that inhibits vascular endothelial growth factor. It is used to treat varied kinds of cancers, such as breast cancer, colorectal cancer, non-small cell lung cancer, high grade glioma and etc. While it do appear to delay cancer progression, it is not a curative approach. Because of its high molecular weight, bevacizumab would be believed to be not cross the blood- brain barrier. However, this theory is to be challenged by series of studies proving the efficacy of bevacizumab in brain tumor. On account of lack of vital information about safety events and increasing risk of intra-cranial hemorrhage, Food and Drug Administration (FDA) lifted the ban on use of bevacizumab in colorectal cancer with brain metastasis since several years ago. Therefore, the reports of use of bevacizumab in colorectal cancer with brain metastasis are limited. Here, we presented a case of colorectal cancer with brain metastasis, and the brain lesion got shrinkage after starting bevacizumab in combination with chemotherapy. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。