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題名 | MicroRNA-based Therapy in Pain Medicine: Current Progress and Future Prospects |
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作者姓名(外文) | Tan, Ping-heng; Pao, Yun-ying; Cheng, Jen-kun; Hung, Kuo-chuan; Liu, Chien-cheng; | 書刊名 | Acta Anaesthesiologica Taiwanica |
卷期 | 51:4 2013.12[民102.12] |
頁次 | 頁171-176 |
分類號 | 418.224 |
關鍵詞 | Inflammation; MicroRNAs; Pain; Neuropathic; Visceral Pain; |
語文 | 英文(English) |
英文摘要 | MicroRNAs (miRNAs) are small noncoding RNA molecules of 18e25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulate gene and protein expression associated with the induction and chronification of pain. Thus, miRNAs might have promise in therapy and as a diagnostic and prognostic biomarker in pain medicine. The application of miRNA has been an emerging field in pain research in recent years. Many studies focusing on the regulation of miRNAs under different tissue and nociceptive stimuli have been performed in recent years. In this review, we intend to introduce the most recent research in the field of miRNA related with pain medicine such as the expression and function of miRNA in different animal pain model, the challenge of application and delivery of miRNA in vivo, the potential toxic effects of miRNA and future problems in clinical application that need to be resolved. This review focuses on the results of miRNA in animal studies and the prospect for future success. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。