頁籤選單縮合
題 名 | Efficacy of Femarelle for the Treatment of Climacteric Syndrome in Postmenopausal Women: An Open Label Trial |
---|---|
作 者 | Chen, Fang-ping; Chang, Chee-jen; Chao, An-shine; Huang, Hong-yuan; Huang, Jian-pei; Wu, Meng-hsing; Tsai, Ching-chou; Kung, Fu-tsai; Chang, Ching-wen; Tsai, Yung-chieh; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷 期 | 55:3 2016.06[民105.06] |
頁 次 | 頁336-340 |
分類號 | 417.224 |
關鍵詞 | Climacteric syndrome; Femarelle; Hot flushes; Postmenopausal women; |
語 文 | 英文(English) |
英文摘要 | Objective: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. Materials and methods: A multi-center, open-label trial of 260 postmenopausal women, age三 45 years with vasomotor symptoms. Women were enrolled after obtaining a detailed medical history and a thorough physical examination. They then received Femarelle (640 mg/d) twice daily for 8 weeks. The primary outcome was the changes in the frequency and severity of hot flushes from baseline to 4 weeks (1 month) and 8 weeks (2 months). Changes of general climacteric syndrome were assessed using a modified climacteric scale designed by Greene. Results: The frequency and severity of hot flushes were significantly improved with Femarelle use (p < 0.001). After 8 weeks of treatment, the percentage of women with various climacteric syndromes was reduced (from 100% to 20.9% for hot flushes, from 97.7% to 87.9% for psychological symptoms, from 93.8% to 78.8% for somatic symptoms, and from 87.8% to 74.9% for sexual symptoms). General climacteric syndrome scores also significantly decreased, from 20.8 ± 0.7 at the time of enrollment to 12.9 ± 0.7 after 8 weeks of Femarelle treatment (p < 0.0001). Participants experienced improvement of various climacteric symptoms and signs after 8 weeks of treatment (75.1% for hot flushes, 68.7% for psychological symptoms, 70.6% for somatic symptoms, and 69.0% for sexual problems respectively). After 4 weeks and 8 weeks of treatment with Femarelle, patients showed statistically significant improvement in climacteric symptoms (p < 0.0001). Three women (1.2%) withdrew from the study after 4 weeks of treatment due to adverse effects. Conclusion: Femarelle significantly improved climacteric symptoms in Taiwanese postmenopausal women. However, further evaluation is needed regarding the safety of long-term consumption. Copyright © 2016, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
本系統中英文摘要資訊取自各篇刊載內容。