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題名 | Transport of Zidovudine-and Lamivudine-loaded Polybutylcyanoacrylate and Methylmethacrylate-sulfopropylmethacrylate Nanoparticles across the In Vitro Blood-brain Barrier: Characteristics of the Drug-delivery System=Zidovudine和Lamivudine負載於Polybutylcyanoacrylate和Methylmethacrylate-sulfopropylmethacrylate奈米粒子上的生體外血腦屏障穿透:藥物釋放系統的特性 |
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作者 | 郭勇志; 鍾秋燕; | 書刊名 | Journal of the Chinese Institute of Chemical Engineers |
卷期 | 36:6 民94.11 |
頁次 | 頁627-638 |
分類號 | 460.02 |
關鍵詞 | 生體外血腦屏障; 穿透行為; 奈米粒子; Blood-brain barrier; Zidovudine; Lamivudine; Polybutylcyanoacrylate; Methylmethacrylate-sulfopropylmethacrylate; Nanoparticle; |
語文 | 英文(English) |
中文摘要 | 本文探討負載polybutylcyanoacrylate (PBCA)和methylmethacrylate-sulfopropylmethacrylate (MMA-SPM)上的zidovudine (AZT)和lamivudine (3TC)對生體外血腦屏障的穿透行為。牛腦微血管內皮細胞(BBMEC)緻密單層膜可由初代分離與培養的技術獲得,而由免疫細胞化學螢光法,可證實BBMEC的同質均一性和單層膜的緊密細胞間接合。此外,對膠體藥物載體系統而言,PBCA和MMA-SPM奈米粒子的平均粒徑分別為92nm和78nm,且幾乎為單一粒徑分佈。在對BBMEC單層膜的穿透研究中,AZT和3TC結合奈米粒子載體的穿透量遠高於非載體系統的穿透量,這說明了奈米粒子載體可有效改善藥物的腦部標的釋放。由比較此二奈米粒子扮演AZT和3TC載體的功能,可知負戴於PBCA上的穿透量超過負載於MMA-SPM上的一倍半。 |
英文摘要 | Transport study of zodovudine (AZT) and lamivudine (3TC) loaded on polybutylcyanoacrylate (PBCA) and metylmethacrylate-sulforporpylmethacrylate (MMA-SPM) nanoparticles (NPs) across the in vitro blood-brain barrier (BBB) model system was presented. Through primary culture, confluent monolayer of bovine brain-microvascular endothelial cells (BBMECs) with the feature of cellular homogeneity and tight intercellular junction was demonstrated by immunocytochemical fluorescent method, besides, for the colloidal drug-carrier system, average diameters of the two nearly monodispersed PBCA and MMA-SPM nanospheres were, respectively, about 92 nm and 78 nm. The amount of AZT and 3TC across the current BBMEC monolayer in carrier-incorporated system was much higher than that in non-carrier system, suggesting sufficient amelioration in drug transport by employing the NP carriers for brain-targeting delivery. Comparing PBCA NPs with MMA-SPM NPs, the amount of drug (AZT and 3TC) across the in vitro BBB system for the former was in excess of 1.5 times that for the latter. |
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