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頁籤選單縮合
題名 | CA125-producing Clear Cell Adenocarcinoma Arising From the Upper Ureter and Renal Pelvis=具有CA125的上輸尿管併腎盂細胞腺癌 |
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作者 | 石濟民; 黃傳德; 紀慶煌; 林瑞偉; 潘競成; Shih, Chi-min; Huang, Chuan-te; Chi, Ching-huang; Lin, Jui-wei; Pan, Chin-chen; |
期刊 | Journal of the Chinese Medical Association |
出版日期 | 20100100 |
卷期 | 73:1 2010.01[民99.01] |
頁次 | 頁40-43+CA7 |
分類號 | 415.8 |
語文 | eng |
關鍵詞 | 透明細胞腺癌; 上泌尿道; CA125; CA19-9; Clear cell adenocarcinoma; Upper urinary tract; |
英文摘要 | Clear cell adenocarcinomas similar to those found in the female genital organs can arise in the lower urinary tract of both women and men. Clear cell adenocarcinomas occurring in the upper urinary system are exceedingly rare. Here, we present a case of clear cell adenocarcinoma arising from the upper ureter and renal pelvis of a postmenopausal woman with a ureteral stone. The patient had elevated serum levels of cancer antigen (CA) 125 (103.80 U/mL) and CA19-9 (151.96 U/mL). The tumor showed typical features of tubulopapillary structures lined with clear-to-eosinophilic cytoplasm and frequent hobnail configuration. The tumor cells were immunoreactive for cytokeratin 7, cytokeratin 20, carcinoembryonic antigen and CA125, but negative for PAX-2 and α-methylacyl coenzyme A racemase. Given the presence of intestinal and squamous metaplasia of the adjacent urothelium, we propose that this clear cell adenocarcinoma developed through a metaplastic process. The tumor behaved so aggressively that the patient developed multiple metastases and died of the disease 5 months after radical nephroureterectomy. |
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