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頁籤選單縮合
題名 | Recoverin-Associated Retinopathy: A Case Report and Literature Review=Recoverin抗體相關之視網膜病變:病例報告及文獻回顧 |
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作者 | 洪如頤; 方怡謨; Hung, Ju-yi; Fang, I-mo; |
期刊 | 中華民國眼科醫學會雜誌 |
出版日期 | 20140400 |
卷期 | 53:1 2014.04[民103.04] |
頁次 | 頁48-54 |
分類號 | 416.746 |
語文 | eng |
關鍵詞 | Recoverin抗體; 視網膜病變; Recoverin-associated retinopathy; Autoimmune retinopathy; Cancer associated retinopathy-like syndrome; |
中文摘要 | 報告一例Recoverin抗體相關之視網膜病變及文獻回顧。方法:病例報告。結果:這位79歲女性來門診時抱怨突發性左眼視力模糊,矯正後最佳視力左眼2/200,右眼20/20。眼底檢查僅發現視網膜小動脈略狹窄,視神經盤輕微蒼白。視野檢查顯示兩眼中央三十度內週邊嚴重缺損,視力較差之左眼出現中央視野喪失。光學同調斷層掃描儀發現左眼黃斑部厚度較薄,視網膜電圖訊號明顯衰退。西方墨點免疫染色血液檢查發現Recoverin抗體。目前未發現癌症病兆,所以診斷病人為Recoverin抗體相關之視網膜病變。結論:根據文獻,癌症相關之視網膜病變被證實和Recoverin等抗體有關,許多案例在過去三十年已被提出並廣泛被接受。此病人臨床表現類似癌症相關之視網膜病變,也發現Recoverin抗體,但追蹤一年半來未診斷任何癌症病兆,過去文獻也曾發表過類似案例,但相對數量較少,因此提出此案例並做文獻回顧。 |
英文摘要 | To report a case of recoverin-associated retinopathy. Method: A case report. Result: A 79-year-old woman complained of sudden blurred vision in her left eye. The corrected visual acuity was 20/20 in the right eye and 2/200 in the left eye. A fundus exam showed attenuation of the arterial vasculature and mild optic disc pallor. Optical coherence tomography revealed thinner macula thickness than that of the fellow eye. The electroretinogram demonstrated a marked decrease. Antibody testing involving Western immunoblots identified recoverin antibodies (23kDa). Serum biomarkers of autoimmune disease were negative. After a series of malignancy surveys, no hematological or solid tumor was found. Therefore, recoverin-associated retinopathy syndrome was impressed and discussed. Conclusion: Cancer-associated retinopathy (CAR) has been documented for the past 30 years and recoverin is the most commonly implicated autoantibody. However, recoverin-associated retinopathy is relatively rare. We offer this case, diagnosed as recoverin-associated retinopathy without malignancy, and an associated literature review. |
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