頁籤選單縮合
題名 | Small-Animal Molecular Imaging with Portable Devices on Clinical Pinhole Single-Photon Emission Computed Tomography Systems= |
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作者 | Hu, Chi-min; Lin, Ming-shien; Su, Kuan-hao; Liu, Ren-shyan; Chen, Jyh-cheng; |
期刊 | Biomedical Engineering: Applications, Basis and Communications |
出版日期 | 20121200 |
卷期 | 24:6 2012.12[民101.12] |
頁次 | 頁485-493 |
分類號 | 414.93 |
語文 | eng |
關鍵詞 | Geometric calibration; Molecular imaging; Pinhole collimator; Single-photon emission computed tomography; |
英文摘要 | We have developed a portable system compatible with various clinical gamma cameras to perform three-dimensional (3D) small-animal molecular imaging. The spatial resolution of this system is close to that of commercial animal imaging systems, although its cost is much lower. Methods: The portable system consists of a rotating stage, a leveling plate, a line source phantom, and a calibration phantom. To obtain high-resolution single-photon emission computed tomography (SPECT) images, we developed several methods for system alignment and applied geometric calibration. The projections of the subject were reimaged according to the calibration parameters and reconstructed by the 3D ordered subsets expectation maximization (OS-EM) algorithm. Results: The resulting images of the microdeluxe phantom showed 2.4-mm cold rods. The image quality of phantom scanning was stable when the portable system was applied to various gamma cameras from different manufacturers. The resultant images of a 99mTc-MDP bone scan of a mouse showed details of the spine, femur, pelvis, and tail. Furthermore, a radiopharmaceutical study of 99mTc-HYNIC-Annexin V on a liver inflammation-induced mouse was carried out to demonstrate the feasibility of this system for small-animal molecular imaging. |
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