頁籤選單縮合
題名 | Hierarchical Structure of the Protein-Protein Interaction Networks |
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作者姓名(外文) | Ng, Ka-lok; Lee, Po-han; Huang, Chien-hung; Fang, Jywe-fei; Hsiao, Han-wan; Tsai, Jeffrey J. P.; | 書刊名 | Chinese Journal of Physics |
卷期 | 44:1 民95.02 |
頁次 | 頁67-77 |
分類號 | 339.8 |
關鍵詞 | |
語文 | 英文(English) |
英文摘要 | We employed the random graph theory approach to analyze data for seven species in the protein-protein interaction database DIP. Several global topological parameters were used to characterize the protein-protein interaction networks (PINs) for each species. The plots of the logarithm of the node degree cumulative distribution Pcum(k) vs. the logarithm of node degree k indicates that PINs follow the power law (Pcum(k) ~ k-α). Good evidence by correlation analysis supports the fact that the seven PINs are well approximated by scale-free networks. We found that the logarithm of Cave(k) scales with k (i.e. Cave(k) ~ k-β) for E. coli and yeast. In particular, we determine that the E. coli and the yeast PINs are well represented by the stochastic and deterministic hierarchical network models, respectively. These results suggest that the hierarchical network model is a good description for certain species’ PINs, but this may not be a universal feature across different species. |
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