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題名 | Obstructive Sleep Apnea and Risk of Gout--A Nationwide Population-Based Study=阻塞性睡眠呼吸中止症與痛風風險--全國健保資料庫研究 |
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作者 | 蘇一峰; 洪任諭; 彭殿王; Su, Vincent Yi-fong; Hong, Jen-yee; Perng, Diahn-warng; |
期刊 | 胸腔醫學 |
出版日期 | 20141000 |
卷期 | 29:5 2014.10[民103.10] |
頁次 | 頁272-280 |
分類號 | 415.472 |
語文 | eng |
關鍵詞 | 阻塞性睡眠呼吸中止症; 睡眠呼吸障礙; 痛風; Obstructive sleep apnea; Sleep-disordered breathing; Gout; |
中文摘要 | 背景:過去研究發現阻塞性睡眠呼吸中止症(Obstructive sleep apnea, OSA)與痛風風險可能有關,但是相關研究非常侷限,大部分的研究是小型的研究、橫斷性研究,或者是缺乏對照組的研究。本研究探討OSA與痛風的風險。方法:從健保資料庫百萬人抽樣檔中,從2000年1月至2008年12月,選出有OSA的成年患者,對照組則選配同性別與年齡的無OSA的成年患者,兩組患者分別追蹤到2008年12月或者痛風的發生為止。結果:總共選取了21,817名的患者,其中4,365名OSA患者,17,452名對照組患者。在平均6.58年追蹤時間中,1,111(5.09%)人發生痛風,OSA組其中有212人發生痛風,佔4.86%;而對照組中有899人發生痛風,佔5.15%。痛風發生曲線以Kaplan-Meier法分析,在痛風發生率上兩組並無統計學上的差異(p=0.499),在多因子校正分析之後,OSA不是痛風的危險因子。結論:OSA可能不會增加痛風的發生率。 |
英文摘要 | Introduction: Studies evaluating the risk of gout in patients with obstructive sleep apnea (OSA) are limited. Most of them are small in sample size, cross-sectional in design or lack appropriate controls and information associated with gout development. We designed this study to explore the risk of incident gout in adult patients with OSA. Methods: From Jan. 1, 2000, we identified adult patients with OSA from the Taiwan National Health Insurance Research Database. A control cohort without OSA, matched for age and sex, was selected for comparison. The 2 cohorts were followed up until Dec. 31, 2008 or occurrence of gout. Results: Of the 21,817 subjects (4,365 OSA patients vs. 17,452 matched controls), 1,111 (5.09%) suffered from gout during a mean follow-up period of 6.58 years, including 212 (4.86%) in the OSA cohort and 899 (5.15%) among the controls. Kaplan-Meier analysis revealed that there was no difference in the incidence of gout between the OSA cohort and the matched cohort (log rank test, p = 0.499). After multivariate adjustment, OSA was not an independent risk factor for gout. Conclusions: OSA did not increase the risk of future gout. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。