頁籤選單縮合
題 名 | Adult Intracranial Germ Cell Tumors in Taiwan=成人顱內生殖細胞瘤 |
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作 者 | 許育瑞; 何景良; 陳宇欽; 高偉堯; 趙祖怡; | 書刊名 | Journal of Medical Sciences |
卷 期 | 23:5 2003.10[民92.10] |
頁 次 | 頁265-269 |
分類號 | 415.938 |
關鍵詞 | 顱內生殖細胞瘤; Central nervous system; Chemotherapy; Germ cell tumor; Germinoma; Radiotherapy; |
語 文 | 英文(English) |
英文摘要 | Background: Primary germ cell tumors (GCT) of the central nervous system are rare. The majority of investigations of intracranial GCT were pediatric groups. Information regarding these tumors from Taiwan is limited and our results focus on adult patients. Methods: We retrospectively reviewed the medical records of 23 adult patients with intracranial GCT treated between 1983 and 2002, at a large tertiary care hospital in Taipei. Results: Twenty-one males and 2 females, age range from 16 to 68 years old with a median of 22, were indentified. Their primary tumors were over pineal (n=12), suprasellar (n=6), basal ganglion (n=1) and hemisphere (n=4) regions. Fifteen patients had germinomas and 8 had nongerminomatous GCT, including malignant teratoma (n=4), choriocarcinoma (n=2) and mixed GCT (n=2). Of the 15 patients with germinoma, 10 were treated with radiotherapy (P/T) alone, 3 with debulking surgery followed by R/T, and 2 with debulking surgery alone. Initial complete remission (CR) was achieved in 14 (93.3%) patients. Twelve of 15 patients (80%) remain alive with no evidence of disease at 19-237 months (median, 112.5 months). The 8 patients with CNS nongerminomas were treated with debulking surgery alone (n=1), R/T alone (n=1), debulking surgery followed by R/T (n=2), R/T followed by resection of residual tumor (n=2), and debulking surgery followed by R/T along with chemotherapy (n=2). Three out of the 8 patients remain in CR and are alive with no evidence of disease at 35, 79 and 130 months, respectively. One patient who received salvage chemotherapy remained alive at 35 months after diagnosis. Conclusions: The treatment outcome of adult intracranial GCT was not different from pediatric groups. Optimal treatment modalities are not yet established for intracranial GCT and the role of chemotherapy for improving survival needs to be explored. |
本系統中英文摘要資訊取自各篇刊載內容。