查詢結果分析
相關文獻
頁籤選單縮合
題 名 | Sesamin Reduces Acute Hepatic Injury Induced by Lead Coupled with Lipopolysaccharide |
---|---|
作 者 | Chiang, Hsiu-mei; Chang, Hsiang; Yao, Pei-wun; Chen, Yuh-shuen; Jeng, Kee-ching; Wang, Jen-shu; Ho, Chien-wei; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 77:5 2014.05[民103.05] |
頁 次 | 頁227-233 |
分類號 | 368.65 |
關鍵詞 | Cyclooxygenase-2; Inducible nitric oxide synthase; Kinases; Mitogen-activated protein; Sesamin; |
語 文 | 英文(English) |
英文摘要 | Background: In this study, we investigated the potential anti-inflammatory and antioxidative effects of sesamin on acute liver injury. Lead (Pb) causes oxidative damage and enhances the effects of low-dose lipopolysaccharide (LPS), inducing acute hepatic injury in rats. Methods: Male SpragueeDawley rats were given intraperitoneal injections of Pb acetate (5 mg/kg) and LPS (50 mg/kg) to induce liver injury, and we tested the effects of oral administration of sesamin (10 mg/kg) on liver damage. To assess the extent of acute hepatic injury in the rats, we measured the anti-inflammatory and antioxidant markers and relevant signaling pathways: serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), reactive oxygen species (ROS), tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, nitric oxide (NO), and cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) levels, mitogen-activated protein kinases (MAPKs), c-Fos, and GADD45b. Results: Sesamin significantly decreased the serum AST, ALT, and CRP levels in the rat model. In the Pb and LPS-stressed rats, sesamin administration reduced the serum levels of TNF-a, IL-1, IL-6, NO, and ROS generation, and liver tissue expressions of c-Jun N-terminal kinase (JNK), p38 MAPK, GADD45b, COX-2, and iNOS. Conclusion: Collectively, these results demonstrate that sesamin is associated with antioxidant and anti-inflammatory activity. The observed effect of scavenging of ROS and NO and inhibiting the production of proinflammatory cytokines may be achieved through the suppression of COX-2, iNOS, and MAPK pathways in the acute hepatic injury rats. |
本系統中英文摘要資訊取自各篇刊載內容。