頁籤選單縮合
題 名 | Aortic Arch Calcification, Inflammation and Premature Death in Non-Diabetic Patients with Chronic Peritoneal Dialysis |
---|---|
作 者 | Lee, Cheng-chia; Juan, Kuo-chang; Chen, Kuan-hsing; Weng, Chu-man; Jenq, Chang-chyi; Tian, Ya-chung; Chang, Ming-yang; Yang, Chih-wei; Hung, Cheng-chieh; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷 期 | 29:1 2015.03[民104.03] |
頁 次 | 頁27-36 |
分類號 | 415.74 |
關鍵詞 | Aortic arch calcification; Inflammation; Peritoneal dialysis; Premature death; |
語 文 | 英文(English) |
英文摘要 | BACKGROUND: Vascular calcification is a highly prevalent complication in end stage renal disease patients and is associated with increased morbidity and mortality. Measurement of aortic arch calcifi cation (AoAC), as assessed by chest X-ray (CXR), is a simple method to evaluate vascular calcifi cation. The clinical signifi cance of AoAC in non-diabetic peritoneal dialysis (PD) patients remained unknown. METHODS: 272 non-diabetic PD patients were enrolled into this study. Baseline geographic and biochemical data were obtained as well as CXR were assessed for the AoAC. The factors determining higher AoAC and infl ammatory marker as denoted by high-sensitivity C-reactive protein (hsCRP) were analyzed. Cox proportional hazards models were used to investigate the risk factors of all-cause mortality. RESULTS: Patients with high-AoAC had a trend of higher corrected calcium, log hsCRP, log intact parathyroid hormone, and lower serum albumin level. Using multivariate logistic regression analysis, corrected calcium and log hsCRP remained associated with high-AoAC independently. After follow-up for 54 months, 31 patients (11.4%) died. Kaplan-Meier analysis showed that patients with high-AoAC had a signifi cantly higher all-cause (P < 0.000001) and cardiovascular mortality (P < 0.001) than those with low-AoAC. Likewise, subgroup analysis for patients younger than 55 years old showed similar results, suggesting a premature death with higher AoAC. Cox proportional hazards model demonstrated that age, serum albumin and high-AoAC signifi cantly predicts all-cause mortality in chronic non-diabetic PD patients. CONCLUSION: Our data demonstrate that AoAC not only may reflect disturbed mineral bone metabolism and inflammation status but also predict all-cause mortality in non-diabetic PD patients even in young age group. These data suggest that AoAC by CXR is a cost-effective method to provide prognostic information in this population. |
本系統中英文摘要資訊取自各篇刊載內容。