頁籤選單縮合
題名 | Mosquito Larvicidal Activity of Broussonetia papyrifera Compound Marmesin by Blocking Protein AeSCP-2, Docking Strategies, and Combined Effect of Copepod Megacyclops formosanus Against Dengue Vector Aedes aegypti (Diptera: Culicidae) |
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作者 | Kalimuthu, Kandasamy; Wang, Chia-hsiang; Liu, Shiu-mei; Tseng, Li-chun; Murugan, Kadarkarai; Hwang, Jiang-shiou; | 書刊名 | Journal of Marine Science and Technology |
卷期 | 21:suppl 2013.12[民102.12] |
頁次 | 頁308-315 |
分類號 | 387.795 |
關鍵詞 | Aedes aegypti; Broussonetia papyrifera; Sterol carrier protein-2; Marmesin; Larvicidal; |
語文 | 英文(English) |
英文摘要 | Mosquito-borne diseases that have an economic impact create losses in commercial and labor outputs, particularly in countries with tropical and subtropical climates. The emergence of resistance to synthetic insecticides is a challenge to mosquito control. Cyclopoid copepods are important predators in many aquatic ecosystems and have been successfully used as biological agents to control mosquito larvae. For this study, we examined the larvicidal activity of the copepod Megacyclops formosanus in combination with the compound marmesin (which was purified from the methanol crude extract of the plant stem bark of Broussonetia papyrifera) against Aedes aegypti larvae. Their larvicidal activity and in silico docking analysis regarding the inhibition of the binding cholesterol sterol carrier protein-2 (AeSCP-2) against A. aegypti were evaluated. The significant larvicidal potential was recorded after the marmesin plant compound treatment against the dengue vector A. aegypti. Larval mortality was observed after 24 h of exposure. The LC50 and LC90 of marmesin against the first to fourth instar larvae and pupae were 0.104, 0.115, 0.137, 0.176, and 0.353 ppm, and 0.255, 0.270, 0.297, 0.365, and 0.643 ppm, respectively. This study showed that marmesin and copepods can be used effectively for mosquito larvae control programs. This is an ideal eco-friendly approach for controlling A. aegypti larvae. |
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