頁籤選單縮合
題名 | 2008~2012年國內侵襲性肺炎鏈球菌之抗生素感受性分析=Original Article Antimicrobial Susceptibility of Invasive Streptococcus pneumoniae in Taiwan, 2008~2012 |
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作者 | 陳英彥; 姚淑滿; 陳雅惠; 蔣世峯; 郭宗霖; 高培修; 鄭麗容; 王昱嵐; 江春雪; | 書刊名 | 疫情報導 |
卷期 | 29:19 2013.10.08[民102.10.08] |
頁次 | 頁284-292 |
分類號 | 415.2713 |
關鍵詞 | 侵襲性肺炎鏈球菌感染症; 抗生素最低抑菌濃度; 血清型19A; Invasive pneumococcal disease; Minimal inhibition concentration; Serotype 19A; |
語文 | 中文(Chinese);英文(English) |
中文摘要 | 2008年 1月至 2012年 12月,針對 3,643株分離自國內侵襲性肺炎鏈球菌感染症確定個案的肺炎鏈球菌菌株,進行抗生素最低抑菌濃度試驗。分析菌株對各類抗生素具有感受性的比例:對青黴素類抗生素 amoxicillin及 penicillin分別為79.9%及 55.0%,對第三及第四代頭芽孢菌素類抗生素cefotaxime及cefepime分別為 69.2%及 59.3%,對 quinolones類的抗生素 levofloxacin及 moxifloxacin分別為94.7%及 95.3%,對 chloramphenicol、linezolid、telithromycin及 vancomycin分別為 73.8%、99.8%、94.6%及 100.0%,對 cabapenems類的 meropenem及磺胺類的trimethoprim-sulfamethoxazole的感受性較低,分別為 36.4%及 39.4%,對erythromycin、tetracycline及 clindamycin的感受性最低,分別為 9.6%、9.0%及 24.4%。依菌株分離年代分析,對 cefepime、clindamycin及 meropenem具有感受性菌株的比例呈現逐年下降的趨勢,而對amoxicillin及 cefotaxime只持續下降到 2011年,2012年分別回升到 73.1%及 72.9%。血清型 19A肺炎鏈球菌的感染在近幾年不斷地增加,已成為國內最主要流行的血清型別,這型菌株對 amoxicillin、cefepime、cefotaxime、meropenem及 penicillin不具感受性的比例很高(81.6%~97.2%),且感染 5歲以下幼童的比例最高,因此使得這個年齡層的感染菌株對這幾種抗生素具有感受性比例相較其他年齡層低(13.0%~54.8%)。本研究顯示我國在進行侵襲性肺炎鏈球菌感染症的防治策略,除了預防性的疫苗接種外,仍應注意該病原菌的抗藥性問題。 |
英文摘要 | From January 2008 to December 2012, a total of 3,643 Streptococcus pneumoniae strains isolated from the confirmed cases of invasive pneumococcal disease were tested for the minimal inhibition concentrations (MIC) toward various antimicrobial agents. The susceptibility rates were 79.9% and 55.0% toward penicillins-type antimicrobial agents, amoxicillin and penicillin, respectively; 69.2% and 59.3% toward the third and the fourth generation cephalosporins, cefotaxime and cefepime, respectively; 94.7% and 95.3% toward quinolones-type antimicrobial agents, levofloxacin and moxifloxacin, respectively; 73.8%, 99.8%, 94.6% and 100.0% toward chloramphenicol, linezolid, telithromycin and vancomycin, respectively. The susceptibility rates were lower toward cabapenems-type antimicrobial agent, meropenem, and the sulfonamide-type antimicrobial agent, trimethoprim/sulfamethoxazole, 36.4% and 39.4%, respectively. The susceptibility rates toward erythromycin, tetracycline and clindamycin were the lowest, 9.6%, 9.0% and 24.2%, respectively. The susceptibility rates toward cefepime, clindamycin and meropenem continued to decline by year. The susceptibility rates toward amoxicillin and cefotaxime declined by year till 2011, and increased to 73.1% and 72.9% in 2012, respectively. In recent years, invasive infections caused by serotype 19A S. pneumoniae continued to increase and serotype 19A S. pneumoniae has become the most prevalent serotype in Taiwan. The non-susceptibility rates of serotype 19A S. pneumoniae towards amoxicillin, cefepime, cefotaxime, meropenem and penicillin were high, ranging from 81.6% to 97.2%. Among children younger than 5 years old, the highest proportion of infections was caused by serotype 19A S. pneumoniae, thus, the susceptibility rates toward the above mentioned antimicrobial agents among this age group were lower than those among other age groups, ranging from 13.0% to 54.8%. For strategies involved in prevention and treatment of invasive pneumococcal diseases, the result of this study indicated that antimicrobial resistance of S. pneumoniae was another issue that is required a close attention, in addition to the usage of vaccines. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。