頁籤選單縮合
題名 | Interleukin-18 and Coronary Artery Lesions in Patients with Kawasaki Disease |
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作者 | Weng, Ken-pen; Hsieh, Kai-sheng; Huang, Shih-hui; Ou, Shan-f; Lai, Tsung-jen; Tang, Chia-wan; Lin, Chu-chuan; Ho, Tsyr-yuh; Liou, Huei-han; Ger, Luo-ping; | 書刊名 | Journal of the Chinese Medical Association |
卷期 | 76:8 2013.08[民102.08] |
頁次 | 頁438-445 |
分類號 | 415.15 |
關鍵詞 | Coronary artery lesions; Interleukin-18; Kawasaki disease; |
語文 | 英文(English) |
英文摘要 | Background: Interleukin-18 (IL-18) plays an important role in mediating cytokine cascade leading to coronary artery lesions (CALs) in Kawasaki disease (KD). However, our research suggested that the literature regarding IL-18 and KD is limited. Consequently, this study aimed to evaluate the correlation between IL-18 and CALs in patients with KD. Methods: In this prospective study of 14 children with KD (seven without and seven with CALs in the acute phase), we obtained patient measurements of a series of serum IL-18 levels in the acute, subacute, and convalescent phases. Serum IL-18 levels were measured with a Bio-Plex cytokine assay. Control samples were obtained from 18 febrile children with viral infection. Results: Compared with febrile controls, patients with acute-stage CALs [postintravenous immunoglobulin (post-IVIG) period] had a significantly higher IL-18 level (88.4 ± 20.7 vs 56.0 ± 35.0 pg/mL, p = 0.006). However, those without acute-stage CALs (post-IVIG period) lacked similarly elevated IL-18 level readings (62.0 ± 40.6 vs 56.0 ± 35.0 pg/mL, p = 0.762). The IL-18 level of patients with acute-stage CALs did not decrease significantly until the convalescent phase (97.4 ± 55.8 vs 38.7 ± 22.6 pg/mL, p = 0.018), but for those without CALs, it decreased significantly in the subacute phase (60.2 ± 37.4 vs 23.6 ± 13.8 pg/mL, p = 0.018). In the subacute stage, there was a significant difference of IL-18 level between patients with and without acute-stage CALs ( p = 0.048). Conclusion: Our data show that IL-18 levels were elevated in the acute phase of KD and might be related to the formation of CALs. |
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