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頁籤選單縮合
題名 | Factors Predicting Local Recurrence in Rectal Cancer after Curative Surgery=影響直腸癌術後局部復發的因子 |
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作者姓名(中文) | 朱峻廷; 王瑞和; 金台明; 許詔文; | 書刊名 | 中華民國大腸直腸外科醫學會雜誌 |
卷期 | 24:4 2013.12[民102.12] |
頁次 | 頁122-128 |
分類號 | 416.245 |
關鍵詞 | 局部復發; 直腸癌; 預測因子; 癌胚抗原; Local recurrence; Rectal cancer; Predicting factor; CEA; |
語文 | 英文(English) |
中文摘要 | 目的:本篇研究的目的在找尋可能影響局部復發的相關臨床或病理因子對於第一期至第三期直腸癌術後的病人且術前並無接受化學放射治療。方法:從2005年5月至2008年12月,178位第一期至第三期直腸癌術後並有規則追蹤的病人被收錄與分析。利用單變項與多變項分析來找出可能影響直腸癌術後局部復發的相關臨床或病理因子。結果:術後局部復發有25位(14%)病人。單變項分析發現,局部復發與腫瘤位置(p = 0.046)、血管侵犯(p = 0.001)、神經侵犯(p = 0.001)、較高的術前癌胚抗原(p < 0.001)、腫瘤侵犯的深度(p = 0.047)、淋巴結侵犯(p = 0.008)、遠端切除範圍小於1公分(p = 0.001)及遠端切除範圍小於2公分(p = 0.025)有明顯的相關性。在多變項分析中,局部復發與較高的術前癌胚抗原(p = 0.001)及遠端切除範圍小於1公分(p = 0.030)有直接相關。討論:這個研究發現較高的術前癌胚抗原及遠端切除範圍小於1公分是直腸癌術後局部復發重要的危險因子。對於高危險的病人給予術後密切的追蹤及積極的治療是需要的。 |
英文摘要 | Purpose. The aim of this study was to identify possible clinicopathological predictor of local recurrence (LR) of Stage I-III rectal cancer in patients undergoing curative resection without pre-operative neoadjuvant concurrent chemo-radiotherapy.Methods. Between May 2005 and December 2008, a total of 178 patients with Stage I-III rectal cancer who had undergone curative resection and received regular follow-up were retrospectively analyzed. Possible clinicopathological risk factors of rectal cancer LR were analyzed using univariate and multivariate methods.Results. Postoperative LR was found in 25 (14%) patients. Univariate analysis indicated LR to be significantly correlated with lesion location (p = 0.046), vascular invasion (p = 0.001), perineural invasion (p = 0.001), high pre-operative carcinoembryonic antigen (CEA) level (p < 0.001), depth of invasion (p = 0.047), nodal invasion (p = 0.008), distal resection margin < 1 cm (p = 0.001), and distal resection margin < 2 cm (p = 0.025). Multivariate analysis revealed LR to be significantly correlated with high pre-operative CEAlevels (p = 0.001) and distal resection margin < 1 cm (p = 0.030).Conclusions. The results of this study suggest that pre-operative CEA level and distal resection margin < 1 cm are important independent predicative factors for the development of the LR of rectal cancer after curative resection. Close follow up of these high-risk patients and intensive treatment after curative resection may be indicated. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。