查詢結果分析
來源資料
相關文獻
- 薏苡仁酯對內皮細胞發炎相關細胞激素之影響
- 細胞激素,發炎反應與免疫生物製劑
- 間歇性低氧:阻塞型睡眠呼吸中止症引起之代謝症候群的致病原因與治療方向
- 補充麩醯胺對敗血症小鼠肝臟發炎反應及氧化壓力之影響
- 嚴重外傷後白血球功能與細胞激素改變及臨床預後之關係
- EMR2 Receptor Ligation Modulates Cytokine Secretion Profiles and Cell Survival of Lipopolysaccharide-treated Neutrophils
- 中草藥對於促發炎細胞激素生成之影響
- The Potential Application of Granulocyte Colony Stimulating Factor Therapy on Neuropathic Pain
- 鎂對運動與免疫功能之影響
- 耐力訓練對輔助型T細胞的影響
頁籤選單縮合
題名 | 薏苡仁酯對內皮細胞發炎相關細胞激素之影響=Influences of Endothelial Cell Inflammatory Mediators by Coixenolide |
---|---|
作者 | 許淳惟; 許淳彰; 冼紹祥; 吳宏乾; | 書刊名 | 北臺灣中醫醫學雜誌 |
卷期 | 4:2 2012.12[民101.12] |
頁次 | 頁11-24 |
分類號 | 414.51 |
關鍵詞 | 發炎反應; 內皮細胞; 薏苡仁酯; 細胞激素; Inflammation; Endothelial cell; Coixenolide; Cytokine; |
語文 | 中文(Chinese) |
中文摘要 | 1976年,Ross提出動脈硬化形成的發炎反應(inflammation)病理學說,隨著時代的進步,也越來越多的證據顯示,局部和全身發炎反應在動脈硬化的發生、發展和併發症中起著重要作用。本研究採用脂多糖(LPS)誘發血管內皮細胞的發炎反應,觀察在加入不同濃度的薏苡仁酯(coixenolide)後,內皮細胞產生發炎反應相關的細胞激素,包括促進發炎的細胞激素-TNF-α,和IL-1β,及抑制發炎反應的IL-10及TGF-β,研究coixenolide能否調控發炎反應相關的細胞激素,來抑制內皮細胞發炎反應。實驗結果顯示coixenolide可以有效抑制內皮細胞分泌促進發炎的細胞激素-TNF-α,和IL-1β,和增加抑制發炎反應細胞激素IL-10及TGF-β的分泌量,來達到抑制內皮細胞發炎反應。本研究過程及結果有助於瞭解薏苡仁酯coixenolide之藥理學作用,可作為coixenolide防治心血管疾病更進一步研究的基礎。 |
英文摘要 | In 1976, Ross mentioned that inflammation accelerate atherosclerosis formation. With technological progress, evidences showed that local and systemic inflammation play important roles in the occurrence, development, and complications of atherosclerosis. In this study, lipopolysaccharide (LPS) was used to induce inflammat in cell culture. Treating vascular endothelial cells with different concentrations of coixenolide, the proinflammatory cytokines TNF-α and IL-1β, and anti-inflammatory cytokines IL-10 and TGF-β were examined to elucidate whether coixenolide can regulate inflammation related cytokines. In this study, coixenolide effectively inhibited pro-inflammatory cytokines TNF-α and IL-1β and increased the anti-inflammatory cytokines, IL-10 and TGF-β. It showed that coixenolide inhibits inflammation response of endothelial cells effectively. This research elucidates the pharmacological effect of coixenolide and potentiates the possibility of developing it a new drug on CVD. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。