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題名 | The Early Response of Mannitol Infusion in Traumatic Brain Injury=甘木醇(Mannitol)灌注在腦外傷病變的初早期反應 |
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作者 | 林高章; 周志和; 張偉倫; 柯德鑫; 郭進榮; Lin, Kao-chang; Chou, Chih-ho; Chang, Wei-lung; Ke, Der-shin; Kuo, Jinn-rung; |
期刊 | Acta Neurologica Taiwanica |
出版日期 | 20080300 |
卷期 | 17:1 2008.03[民97.03] |
頁次 | 頁26-32 |
分類號 | 416.291 |
語文 | eng |
關鍵詞 | 甘木醇; 腦; 外傷; Mannitol infusion; Early response; Trascranial doppler; |
英文摘要 | Introduction: Mannitol was used in traumatic brain injury but controversy about the onset and duration. Setting: Clinical observational study. Methods: Fourteen traumatic brain injured patients with a Glasgow Coma Scale (GCS) score ≤8 were enrolled. Group I patients (n=8) with intracranial pressure (ICP) <20 mmHg, and group Ⅱ patients (n=6) with ICP ≥20 mmHg underwent transcranial Doppler (TCD) monitoring and blood samples were drawn every 5 minutes during the post-operation period. Several parameters were compared with statistical analysis between both groups. Results: The ICP declined during a 30-minute recording in both groups and the decline of ICP was significant (p<0.05) at the 10-minute interval in group Ⅱ. The decline of hemoglobin (Hb) and oxygen content (CaO2), increase of venous pressure (CVP) and O2-transport ability (CeDO2) at 10-minute were also statistically significant (p<0.05) in group Ⅱ as compared to the group I. Using a regression model between both comparisons, several parameters were statistically different at the 10-minute interval after mannitol infusion. Conclusions: The dynamic responses can happen as early as 5-10 minutes after mannitol infusion, and had a greater effect on traumatic brain injury patients with ICP ≥20 mmHg. It demonstrated a significant dynamic difference between both groups. All these changes can be monitored by TCD and peripheral blood tests. |
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