頁籤選單縮合
題名 | Sertoli–Leydig Cell Tumor Presenting Hyperestrogenism in a Postmenopausal Woman: A Case Report and Review of the Literature= |
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作者 | Guo, Lili; Yang, Xiang; Zhu, Huiting; Qiu, Weimin; Shi, Xiaofei; Huang, Bingqing; Duan, Tao; |
期刊 | Taiwanese Journal of Obstetrics & Gynecology |
出版日期 | 20121200 |
卷期 | 51:4 2012.12[民101.12] |
頁次 | 頁620-624 |
分類號 | 417.224、417.224 |
語文 | eng |
關鍵詞 | Hyperestrogenism; Postmenopausal bleeding; Postmenopausal woman; Sertoli-Leydig cell tumor; |
英文摘要 | Objective: Sertoli–Leydig cell tumor (SLCT) accounts for <0.5% of all ovarian tumors, which is unusual in postmenopausal women. Postmenopausal women with SLCT usually become virilized. We report a postmenopausal woman with SLCT presenting with hyperestrogenism. Case Report: We report a rare case of SLCT in a postmenopausal woman aged 61 years, who presented with postmenopausal bleeding, endometrial hyperplasia and mucous polyp, elevated estradiol, and decreased follicle-stimulating hormone (FSH) and luteinizing hormone (LH) values, all suggesting hyperestrogenism. Transvaginal ultrasound revealed several small cyst locules, detected inside the right ovary, with a maximum diameter of 7 mm. The diagnosis was delayed because of the atypical clinical manifestation and negative serum tumor markers. The frozen section investigation revealed SLCT intraoperatively, which was confirmed by histopathological and immunocytochemical examination. The tumor was positive for inhibin-alpha, pancytokeratin, and p53 and in isolated tumor cells, positive for Ki-67. Conclusion: This case of SLCT suggests the existence of a new specific type of endocrine complex disease. |
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