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- 柴胡皂苷及薑黃素抑制胎牛血清刺激大鼠肝臟星狀細胞株增殖之體外試驗管內研究
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題 名 | 柴胡皂苷及薑黃素抑制胎牛血清刺激大鼠肝臟星狀細胞株增殖之體外試驗管內研究=The Inhibitory Effects of Saikosaponin A, D and Curcumin on the Activation of Rat Hepatic Stellate Cells by Fetal Bovine Serum in-vitro |
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作 者 | 方怡仁; 楊玉燕; 陳雅菁; 陳明豐; | 書刊名 | 中西整合醫學雜誌 |
卷 期 | 14:2 2012.06[民101.06] |
頁 次 | 頁15-21 |
分類號 | 414.52 |
關鍵詞 | 肝臟星狀細胞; 肝纖維化; 肝硬化; 肝癌; Hepatic stellate cells; Liver fibrosis; Liver cirrhosis; Hepatoma; |
語 文 | 中文(Chinese) |
中文摘要 | 長久以來肝病一直是國人的重大疾病之一,而肝臟發炎後形成肝纖維化是肝硬化的前期病變,其中參與形成肝臟纖維化的主要細胞為星狀細胞。因此,本研究的目的乃建立以胎牛血清體外活化大鼠肝臟星狀細胞株(Hepatic stellate cells; HSCs)的模式,再以柴胡皂苷A、D及薑黃素等成分分別處理HSCs,觀察是否具有抑制HSCs的纖維化作用,以減低肝硬化的發生機率。研究結果發現,高濃度胎牛血清(5-10%)具促進HSCs增生及形態改變的作用。另一方面,柴胡皂苷A、D及薑黃素均具有抑制10%胎牛血清刺激HSCs增生及形態改變的作用。此結果與過去的相關動物體內的研究報告具一致性。我們認為此一體外活化HSCs的模式,將有助於研究抑制肝臟纖維化藥物篩檢的進行。 |
英文摘要 | Liver disease has been a major disease in Taiwan, and liver fibrosis is the early stage of liver cirrhosis after liver inflammation. Among liver pathogenesis, the stellate cells is the major cell type which play a central role in liver fibrosis. Therefore, this study tried to establish an in vitro activated-model of rat hepatic slellate cell line by high concentrations of fetal bovine serum (FBS), and investigated the inhibitory effects of Saikosaponin A, D (SSA, SSD) or curcumin (CCM) on the activation of HSCs by FBS. The results showed that FBS can stimulate the pro life ration and cell type change of HSCs by a dose-dependent manner. On the other hand, SSA, SSD or CCM can inhibit both cell proliferation and morphological change of HSCs induced by 10% FBS. However, the mechanism of these components to inhibit the activation of HSCs induced by 10% FBS is still further studied. |
本系統中英文摘要資訊取自各篇刊載內容。