查詢結果分析
來源資料
相關文獻
- Cerebrospinal Fluid Flow Quantification of the Cerebral Aqueduct in Children and Adults with Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging
- 利用二維相位對比磁振造影技術正常小孩顱內腦脊髓液流量評估
- 中樞神經疾患腦脊髓液的興奮性與抑制性氨基酸
- 顳骨骨折: 220例分析
- Spontaneous Intracranial Hypotension Associated with Simultaneous Rupture of Multiple Perineural Cysts
- Diagnostic Value of Measuring BCG Sonicate Antigen and Anti-BCG Antibodies in the Cerebrospinal Fluid and Blood of Patients with Tuberculous Meningitis
- The Significance of Cerebrospinal Fluid Chloride Concentration in the Central Nervous System Infections
- 臺灣地區腦膜炎奈瑟氏雙球菌引起流行性腦脊髓膜炎的臨床觀察
- 一位腦下垂體腫瘤術後併發腦脊髓液鼻漏病患的護理經驗
- Mondini氏內耳發育不良症併復發性腦膜炎--病例報告
頁籤選單縮合
題名 | Cerebrospinal Fluid Flow Quantification of the Cerebral Aqueduct in Children and Adults with Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging=以二維相位對比磁振造影評估小孩與成人顱內腦脊髓液流量 |
---|---|
作 者 | 范洪春; 江龍輝; 黃騰毅; 阮春榮; 陳震宇; 王安慶; 陳錫洲; | 書刊名 | 輔仁醫學期刊 |
卷期 | 9:2 2011.06[民100.06] |
頁次 | 頁59-72 |
分類號 | 414.93 |
關鍵詞 | 腦脊髓液; 高解析相位對比磁振造影; 有興趣範圍; 峰值流量; 淨搏動量; Cerebrospinal fluid; Two-dimensional cine phase-contrast magnetic resonance imaging; Region of interest; |
語文 | 英文(English) |
中文摘要 | 背景和目的:腦脊髓液的流動與顱內液體的平衡有關,腦脊髓液流動的破壞而影響顱內液體的平衡在小兒與成人會導致不同的疾病。如果能對顱內腦脊髓液的流體動力學能有所了解,對小兒與成人顱內的生理與病理會有更深入的認識。方法:為了評估小兒與成人腦脊髓液的流量的正常值,並希望能做為提供神經疾病診斷的參考依據,我們以高解析相位對比磁振造影技術(phase-contrast MR imaging),來分析比較小兒與成人腦脊髓液的流量的差異。高解析相位對比磁振造影技術,是利用流體波序的雙極梯度與相位對比波序,使流動的氫核的相角與速度成正比,進而分析小兒與成人腦內,在大腦導水管(aqueduct)處腦脊髓液的流量。本研究以峰值流量(peak flow)及淨搏動量(net stroke volume)做評估指標,共有20位小兒受試者(16位男性,4位女性,年齡從7個月至6歲之間),每位受試者為臨床上是複雜性熱痙攣(complex febrile seizures) 的病人,但經醫學影像學檢查及最終臨床診斷無腦部異常者為研究對象;成人共有10 位健康受試者(5位男性,5位女性,年齡從23歲至56歲之間)。結果:正常小孩腦內在腦導水管處腦脊髓液的峰值流量從93.15 μl/s( 微升/秒)到382.4 μl/s不等,平均為200.02 ± 66.4 μl/s,而淨搏動量從1.8 μl/heartbeat(微升/每次心臟搏動)到29.3 μl/s,平均為15.07 ± 11.42μl/heartbeat;成人腦內在腦導水管處腦脊髓液的峰值流量從82.44到146.21 μl/s不等,平均為100.86 ± 18.13 μl/s,而淨搏動量從4 μl/heartbeat到5.82 μl/s,平均為5.09 ± 0.56 μl/heartbeat,兩者相比,發現小孩之腦脊髓液流量與淨搏動量平均值都比成人高出許多。結論:高解析相位對比磁振造影技術是一種方便、精準、非侵入性的技術,此技術除了有助瞭解人類腦脊髓液分泌機轉,以及腦部疾病與腦脊髓液的關係之外,更重要的,從本研究結果發現,對於高解析相位對比磁振造影技術的結果判讀,還必須把病人的年齡加以考慮。 |
英文摘要 | Background and Purpose: Cerebrospinal fluid (CSF) is known to mainly be involved in intracranial homeostatic balance. Disruption of CSF flow may cause distinctive diseases in children and adults. The aim of this study was to characterize CSF flow dynamics in children and adults. Methods: Enrollment criteria for children included (1) a diagnosis of complex febrile seizures, (2) no other neurologic diseases, (3) no cerebral pathology on a brain magnetic resonance imaging (MRI) scan, (4) no cerebrovascular risk factors, and (5) no use of anticonvulsive medications. Ten healthy adults exhibiting no clinical or radiological signs of CSF circulation pathologies were recruited for comparison. To quantify differences in CSF dynamics at the level of the cerebral aqueduct, twodimensional cine phase-contrast (2D cine PC)-MRI was conducted in each subject. CSF flow parameters, including the peak fl ow (μl/s) and net stroke volume (μl/heartbeat) were acquired with an automatic segmentation program that analyzes images, which were retrospectively retrieved from a data storage unit of the MRI instrument. Results: In the children’s group, 20 patients (16 males and 4 females, aged 7 months~6 years) were enrolled. Their mean CSF peak flow was 200.02 ± 66.64 μl/s, and the mean net stroke volume was 15.07 ± 17.42 μl/heartbeat. There were 10 normal adults (5 males and 5 females, aged 23~56 years) with a mean peak fl ow of 100.86 ± 18.13 μl/s and net stroke volume of 5.09 ± 0.56 μl/heartbeat. There were statistically significant differences in the average CSF peak flow and mean net stoke volume between the children’s and adult groups, but no statistical differences in gender, age, or heart rate were seen between these groups. In addition, there was no significant correlation of any parameters between the ≦ 2- and > 2-year-old groups. Conclusions: Values of these flow parameters in children significantly differed from those in adults. Therefore, the age of a patient should be taken into consideration when interpreting these parameters. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。