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題 名 | Prospective Randomized Study of Efficacy of 1-day versus 3-day Antibiotic Prophylaxis for Preventing Surgical Site Infection after Coronary Artery Bypass Graft |
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作 者 | Lin, Mei-hsin; Pan, Sung-ching; Wang, Jiun-ling; Hsu, Ron-bin; Lin Wu, Fei-lin; Chen, Yee-chun; Lin, Fang-yue; Chang, Shan-chwen; | 書刊名 | Journal of the Formosan Medical Association |
卷 期 | 110:10 2011.10[民100.10] |
頁 次 | 頁619-626 |
分類號 | 416.262 |
關鍵詞 | Antibiotic prophylaxis; Coronary artery bypass; Surgical wound infection; |
語 文 | 英文(English) |
英文摘要 | Background/Purpose Despite general recommendation of short-course antibiotic prophylaxis, prolonged antibiotic use is still commonly reported in clinical settings. This study compared the efficacy of 1-day versus 3-day antibiotic prophylaxis in preventing surgical site infection (SSI) in patients undergoing coronary artery bypass graft (CABG). Methods This prospective, randomized control study was performed in a tertiary-care medical center from June 2002 to April 2004. Patients underwent non-emergency CABG and were randomized into two groups receiving either 1 day or 3 days cefazolin prophylaxis. The SSI rates were compared between the two groups. Results During the study period, 231 patients were enrolled, 120 in the 1-day group and 111 in the 3-day group. Twenty-two episodes of SSI were observed within 1 month after operation: 13 (10.8%) in the 1-day group and nine (8.1%) in the 3-day group (odds ratio: 1.37; 95% confidence interval: 0.56–3.33; p = 0.48). By logistic regression analysis, 1-day prophylaxis with cefazolin was not associated with higher risk of SSI (adjusted odds ratio: 0.91; 95% confidence interval: 0.32–2.56; p = 0.85). Conclusion Antibiotic prophylaxis for 1 day in CABG surgery was associated with similar rates of postoperative infection compared with antibiotic prophylaxis of 3 days. |
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