查詢結果分析
相關文獻
- 田口穩健法優化磁流體之合成條件及其應用在熱治療之研究
- 不同莫耳濃度之氯化亞鐵四水合物與氯化鐵六水合物製備之磁性奈米粒子在腫瘤熱治療效益之探討
- 組織間插植熱治療使用熱透導管系統之研究
- The Long-Term Results of One Time Treatment by Continuously Fractionated Transpupillary Thermotherapy for Occult Choroid Neovascularization Membrane of Age-Related Macular Degeneration
- 磁流體之物性及利用
- 插入式熱療天線陣列評估:電腦模擬及假體測試
- 高熱治療所產生之溫度分佈
- Measurements of the Particle Velocity and Flow Pattern of Particles in Magnetically Fluidized Beds
- 磁流體動力發電: 解決酸雨的高度技術
- 電阻點銲之新進展
頁籤選單縮合
題名 | 田口穩健法優化磁流體之合成條件及其應用在熱治療之研究=Optimization of Ferrofluid by Using Taguchi Method and Its Application in Hyperthermia |
---|---|
作者姓名(中文) | 張國平; 林智遠; 洪茂欽; 蔡長書; 李尚熾; 謝柏滄; | 書刊名 | 慈濟技術學院學報 |
卷期 | 17 2011.09[民100.09] |
頁次 | 頁85-103 |
分類號 | 418.9321 |
關鍵詞 | 田口穩健法; 磁流體; 熱治療; Taguchi method; Ferrofluid; Hyperthermia; |
語文 | 中文(Chinese) |
中文摘要 | 熱治療通常被歸類在放射生物領域,而其治療方式當中,有一種是使用磁流體,曝 露在交流電磁場中而使之加熱,其為本研究主要嘗試的方法。我們希望得到在交流磁場 下能容易地加熱且對於腫瘤治療有效的磁流體。除此之外,我們使用田口穩健法來優化 磁流體的製備參數。 利用共沉法合成磁鐵礦奈米粒子與適當地表面修飾後,在交流磁場作用下,溫度的 上升速度隨著磁流體濃度與磁場強度增加而增加。且對於經過表面修飾的磁流體比未經 修飾的產熱率(SAR)高。然後,上升的溫度最後會與周圍環境達到平衡狀態。 TEM 的影像顯示我們合成的粒子平均粒徑為13 nm。XRD 實驗證實其磁性奈米粒 子為Fe3O4 晶型。從SQUID 測出來的磁滯曲線,得知粒子具有超順磁性特徵。表面電位 分析結果顯示,粒子表面帶正電荷。此外,MRI 影像顯示出奈米粒子滯留在腫瘤中。動 物實驗顯示利用本研究之磁性奈米粒子進行的熱治療,對於腫瘤生長有抑制的效果。 |
英文摘要 | Hyperthermia treatment of tumors is a promising branch of radiobiology. One hyperthermia treatment approach uses ferrofluid with an alternating current ( AC ) magnetic field. This study sought to determine the ferrofluid ratio of Fe2+/Fe3+ and the desired reaction conditions which could produce a suspension of nanoparticles having the optimum SAR for use when applying the AC magnetic field method in tumor treatment. Magnetite nanoparticles were prepared based on co-precipitating and proper surface-treatment. When ferrofluids are exposed to an AC magnetic field, the temperature rises quickly, and is relative to the Fe3O4 concentration within the suspension and the intensity of the magnetic field. By means of surface treatment by surfactant, SAR values of the magnetite particles can be greatly enhanced. Under stable conditions, the induced temperatures ultimately remain constant due to the balance of heat generation and heat transfer to the surroundings. Analysis by Taguchi Method determined the optimal parameters for synthesizing a suspension generating the highest SAR value. The nanoparticle suspension with highest SAR was then tested in vivo using mice to confirm its effectiveness in treating the tumors. The TEM results showed the mean diameter of our synthesized nanoparticle was 13 nm. XRD verified the chemical form is Fe3O4. SQUID showed our particle is superparamagnetic from the magnetic hysteresis. Zeta potential analysis justified the magnetite nanoparticle surface has a positive charge, an accepted indicator for the –NH + 3 form. Additionally, upon in vivo testing, the MRI showed the nanoparticles were mostly confined to the tumor area. In conclusion, in clinical applications using AC magnetic field hyperthermia treatment to suppress the growth of tumors, our results offer a more efficient method of synthesizing the optimal ferrofluid suspension. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。