頁籤選單縮合
題 名 | Inhibitory Effects of Polyphenol-enriched Extract from Ziyang Tea against Human Breast Cancer MCF-7 Cells through Reactive Oxygen Species-dependent Mitochondria Molecular Mechanism |
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作 者 | Li, Wenfeng; He, Nianwu; Tian, Lingmin; Shi, Xiaolong; Yang, Xingbin; | 書刊名 | Journal of Food and Drug Analysis |
卷 期 | 24:3 2016.07[民105.07] |
頁 次 | 頁527-538 |
分類號 | 411.47 |
關鍵詞 | Apoptosis; Breast cancer; MCF-7 cells; Polyphenols; Ziyang green tea; |
語 文 | 英文(English) |
英文摘要 | A polyphenol-enriched extract from selenium-enriched Ziyang green tea (ZTP) was selected to evaluate its antitumor effects against human breast cancer MCF-7 cells. In ZTP, (−)-epigallocatechin gallate (28.2%) was identified as the major catechin, followed by (−)-epigallocatechin (5.7%) and (−)-epicatechin gallate (12.6%). ZTP was shown to inhibit MCF-7 cell proliferation (half maximal inhibitory concentration, IC50 = 172.2 μg/mL) by blocking cell-cycle progression at the G0/G1 phase and inducing apoptotic death. Western blotting assay indicated that ZTP induced cell-cycle arrest by upregulation of p53 and reduced the expression of CDK2 in MCF-7 cells. ZTP-caused cell apoptosis was associated with an increase in Bax/Bcl-2 ratio, and activation of caspase-3 and -9. MCF-7 cells treated with ZTP also showed an overproduction of reactive oxygen species, suggesting that reactive oxygen species played an important role in the induction of apoptosis in MCF-7 cells. This is the first report showing that ZTP is a potential novel dietary agent for cancer chemoprevention or chemotherapy. |
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