頁籤選單縮合
題 名 | Intracellular Defenses Against HIV, Viral Evasion and Novel Therapeutic Approaches |
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作 者 | Lever, Robert A; Lever, Andrew M L; | 書刊名 | Journal of the Formosan Medical Association |
卷 期 | 110:6 2011.06[民100.06] |
頁 次 | 頁350-362 |
分類號 | 415.944 |
關鍵詞 | AIDS; HIV; Restriction factor; Retrovirus; |
語 文 | 英文(English) |
英文摘要 | Human immunodeficiency virus (HIV), the causative agent of AIDS, is a retrovirus. It is estimated that, while in the cell, it interacts with almost 10% of cellular proteins. Several of these have evolved to protect the cell from infection with retroviruses and are known as “restriction factors”. Restriction factors tell us much about how the virus functions and open up new paradigms for exploring novel antiviral therapeutics. This article gives an update on the three best studied restriction factors, their putative mechanisms of action and how the virus has overcome their effects, together with an indication of novel therapeutic approaches based on this knowledge. |
本系統中英文摘要資訊取自各篇刊載內容。