頁籤選單縮合
題 名 | Prevalence of Telomerase Activity in Human Cancer |
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作 者 | Chen, Chi-hau; Chen, Ruey-jien; | 書刊名 | Journal of the Formosan Medical Association |
卷 期 | 110:5 2011.05[民100.05] |
頁 次 | 頁275-289 |
分類號 | 415.138 |
關鍵詞 | Biological tumor markers; Cancer diagnosis; Prognosis; Telomere; Telomerase; |
語 文 | 英文(English) |
英文摘要 | Telomerase activity has been measured in a wide variety of cancerous and non-cancerous tissue types, and the vast majority of clinical studies have shown a direct correlation between it and the presence of cancerous cells. Telomerase plays a key role in cellular immortality and tumorigenesis. Telomerase is activated in 80–90% of human carcinomas, but not in normal somatic cells, therefore, its detection holds promise as a diagnostic marker for cancer. Measurable levels of telomerase have been detected in malignant cells from various samples: tissue from gestational trophoblastic neoplasms; squamous carcinoma cells from oral rinses; lung carcinoma cells from bronchial washings; colorectal carcinoma cells from colonic luminal washings; bladder carcinoma cells from urine or bladder washings; and breast carcinoma or thyroid cancer cells from fine needle aspirations. Such clinical tests for telomerase can be useful as non-invasive and cost-effective methods for early detection and monitoring of cancer. In addition, telomerase activity has been shown to correlate with poor clinical outcome in late-stage diseases such as non-small cell lung cancer, colorectal cancer, and soft tissue sarcomas. In such cases, testing for telomerase activity can be used to identify patients with a poor prognosis and to select those who might benefit from adjuvant treatment. Our review of the latest medical advances in this field reveals that telomerase holds great promise as a biomarker for early cancer detection and monitoring, and has considerable potential as the basis for developing new anticancer therapies. |
本系統中英文摘要資訊取自各篇刊載內容。