頁籤選單縮合
題名 | Significant Association of Caveolin-1 Genotypes with Bladder Cancer Susceptibility in Taiwan= |
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作者 | Bau, Da-tian; Chang, Chao-hsiang; Tsai, Ru-yin; Wang, Hwei-chung; Wang, Rou-fen; Tsai, Chia-wen; Yao, Chun-hsu; Chen, Yueh-sheng; Shyue, Song-kun; Huang, Chih-yang; |
期刊 | 中國生理學雜誌 |
出版日期 | 20110600 |
卷期 | 54:3 2011.06[民100.06] |
頁次 | 頁153-160 |
分類號 | 415.837 |
語文 | eng |
關鍵詞 | Caveolin-1; Polymorphism; Bladder cancer; Carcinogenesis; |
英文摘要 | Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on pathological grade. In this case-control study, the association of Cav-1 polymorphisms with bladder cancer risk in a central Taiwanese population was investigated. Three hundred and seventy-five patients with bladder cancer and the same number of age- and gendermatched healthy controls were genotyped. There were significant differences between bladder cancer and control groups in the distributions of their genotypes (P = 1.0 × 10-12 and 0.299) and allelic frequencies (P = 1.4 × 10-14 and 6.2 × 10-3) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for haplotype analysis, subjects who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of bladder cancer compared to subjects with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotypes with smoking status on individual bladder cancer susceptibility. This is the first report providing evidence that Cav-1 was involved in bladder cancer in that the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky haplotype for the development of bladder cancer and may be novel useful genomic markers for early detection of bladder cancer. |
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