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題 名 | The in Vivo Deleterious Effects of Ethanol |
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作 者 | Chen, Yu-hsuan; Chang, Shih-pei; Lu, Ting-chun; | 書刊名 | International Journal of Sport and Exercise Science |
卷 期 | 1:3 2009.07[民98.07] |
頁 次 | 頁81-85 |
分類號 | 411.81 |
關鍵詞 | Senescence-accelerate mice; Oxidative stress; Ethanol; |
語 文 | 英文(English) |
英文摘要 | Oxidative stress, which is defined as an imbalance between pro-oxidants and antioxidants, has been demonstrated to mediate the pathogenesis of ethanol-induced injury. Senescence-accelerated mice prone P8 (SAMP8) is considered an excellent model for rodent aging. However, the deleterious effect of ethanol-induced liver injury of SAM P8 has not been established. In this study we investigated the antioxidant enzyme activities in the liver of SAMP8 during chronic ethanol exposure. The mice were orally administered 0, 0.5, 2 and 4g ethanol/kg BW three times/week for 10 weeks. Results showed that ethanol elevated activity of alanine aminotransferase (ALT) slightly and aspartate aminotransferase (AST) levels were increased significantly in ethanol-fed 0.5 and 4 g/kg BW groups. Hematoxylin and eosin staining indicated moderate to severe fatty infiltration but not fibrosis. Ethanol also enhanced the formation of malondialdehyde (MDA) and protein carbonyls in the liver, whereas ethanol treatment resulted in significantly lower activity of hepatic glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD). We conclude that ethanol damaged the liver of SAMP8 by increasing oxidative stress. |
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