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題名 | Augmented Functioning Free Muscle Transplantation (A-FFMT)--Experimental Rat Study=加強性游離功能性肌肉移植(A-FFMT)--大鼠實驗研究 |
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作者 | 張淑茵; 陳廣得; 莊垂慶; Chang, Shu-ying; Chen, Kuang-te; Chuang, David Chwei-chin; Hoshino, Shushi; |
期刊 | 臺灣整形外科醫學會雜誌 |
出版日期 | 20101200 |
卷期 | 19:4 2010.12[民99.12] |
頁次 | 頁327-336 |
分類號 | 416.45 |
語文 | eng |
關鍵詞 | 游離功能性肌肉移植; A-FFMT; Functioning muscle transplantation; Augmentation; |
中文摘要 | 背景:游離功能性肌肉移植(free functioning muscle transplantation, FFMT)是目前普遍使用來治療功能缺失的顯微重建技術,尤其是對於肢體的重建。然而,目前尚未有研究使用FFMT於正常者以增進功能或美觀,我們稱此爲加強性游離功能性肌肉移植(augmented-FFMT, A-FFMT)。FFMT對於正常肢體的影響也仍未知。目的及目標:此研究的目的是藉由大鼠實驗探討加強性游離功能性肌肉移植使用於正常肢體的可行性及潛力。材料及方法:我們將正常大鼠(Lewis inbred rat)的二頭肌轉移至另一正常大鼠的手臂上,並利用尺神經作爲神經來源。手術步驟和一般游離功能性肌肉移植相同。10隻老鼠在6個月後接受評估:包括手臂圍大小測量,電生理學檢查,手肘彎曲力量檢查,以及肌肉尺寸大小。並以對側手臂爲對照組做比較。結果:所有測量結果顯示轉移後手臂肌肉尺寸及功能都有顯著的增加,且A-FFMT不會對原本存在的二頭肌造成影響。結論: A-FFMT可以增加原本肌肉的大小以及功能。本篇研究證實了A-FFMT使用於正常肢體以促進功能加強及美觀的可行性以及潛力。 |
英文摘要 | Background: Functioning free muscle transplantation (FFMT) is an advanced microneurovascular technique which has been now popularly used to restore functional deficit(s) especially in limbs. However, so far no one uses the technique of FFMT on a normal subject for either functional and/or aesthetic purposes. We called here the additional FFMT for augmentation purpose as "Augmented FFMT (A-FFMT)". No one knows the effect of the A-FFMT on the normal limb. Will the A-FFMT promote or interfere with limb function? If the A-FFMT is proven not only to achieve an aesthetic purpose, but also to promoting functional strength, it will be a new application for the FFMT. Aim and Objectives: The purpose of this study is to investigate the feasibility and potentiality of the A-FFMT in a normal limb through the experimental rat study. Material and Methods: A biceps muscle from one Lewis inbred rat was harvested and transferred to the arm of another healthy Lewis inbred rat. The ulnar nerve was used as the neurotizer. The procedure was the same as a routine FFMT. Ten rats which received augmented biceps muscle transplantation were evaluation six months after surgery. Outcome measurements included arm circumference, electrophysiological studies, elbow flexion force (individual and combined biceps contraction force), and muscle mass. The non-operative limb was used as the control. Results: All outcome measurements revealed that the augmented biceps resulted in significantly increased size and function of the operative limb without interfering with the original biceps. Conclusion: An A-FFMT can enhance the original muscle not only in size but also in function. Our study demonstrates the possibility and potentiality of using an A-FFMT for "functional" and "aesthetic" purposes in a normal subject. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。