頁籤選單縮合
題 名 | Kinetics and Involvement of Interleukin-17 in the Outcome of Peritonitis in Nondiabetic Patients Undergoing Peritoneal Dialysis |
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作 者 | Wang, Hsin-hui; Lee, Tzong-yann; Lin, Ching-yuang; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 74:1 2011.01[民100.01] |
頁 次 | 頁11-15 |
分類號 | 415.57 |
關鍵詞 | IL-17; Outcome; Peritoneal dialysis; Peritonitis; |
語 文 | 英文(English) |
英文摘要 | Background: Peritonitis is the most serious complication of peritoneal dialysis (PD). We previously showed that high levels of interleukin (IL)-12 and IL-18 in PD effluents (PDE) during the early phase of peritonitis correlated with a predominant Type 1 immune response and a favorable outcome in PD-related peritonitis. To further clarify the longitudinal changes of peritoneal immunity during PD-related peritonitis, we examined the kinetic production of IL-17 in PDE during peritonitis. The correlation between the IL-17 expression pattern and peritonitis outcome was analyzed. Methods: The levels of IL-17 were measured in PDE during various phases of peritonitis in 38 patients undergoing PD. The patients were divided into two groups, according to whether they had a rapid versus a delayed response to antibiotic treatment. Results: The kinetic expression of IL-17, as measured by enzyme-linked immunosorbent assay, differed between the two groups. In the rapid response group, high level of IL-17 was detected in PDE initially and progressively decreased during treatment. In the delayed response group, IL-17 levels in PDE were persistently low throughout the whole course of treatment. In the early phase of peritonitis, the IL-17 levels in PDE were significantly higher in the rapid response group ( p < 0.05). Conclusion: These data suggested that local IL-17 production is part of a protective early immune response to PD-related peritonitis. High levels of IL-17 in PDE during the early phase of peritonitis correlated with a favorable outcome. Manipulation of IL-17 cytokine expression in patients with peritonitis may modulate peritoneal immune response and affect peritonitis outcome. |
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