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頁籤選單縮合
題名 | 食道靜脈曲張出血案例與治療介紹=Introduction of Esophagus Varicosity Hemorrhage Case and the Treatment |
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作者姓名(中文) | 蔡佩玲; 李佳靜; | 書刊名 | 藥學雜誌 |
卷期 | 26:4=105 2010.12[民99.12] |
頁次 | 頁63-68 |
分類號 | 415.515 |
關鍵詞 | 肝硬化; 食道靜脈曲張; 血管加壓素; Liver cirrhosis; Esophagus varices; Vasopressin; |
語文 | 中文(Chinese) |
中文摘要 | 約50-70%的肝硬化病人會發生食道靜脈曲張的併發症。初期預防:發現中重度的胃食道靜脈曲張時,可使用非選擇性的β阻斷劑,有禁忌的病患就須選擇門脈結紮手術;疑似出血的治療:使用血管加壓素 vasopressin類藥物有 vasopressin(Pitressin)、 terlipressin(Glypressin),體抑素 somatostatin類包括 octreotide(Sandostatin)、 somatostatin(Stilamin)。二期預防: 50%的病患會發生再出血的症狀,其後續治療方式可發現其再出血的機率以未治療的出血率最大,可合併使用非選擇性的β阻斷劑與 Nitrates而降低再出血率到 30%。 |
英文摘要 | Approximately 50-70% of liver cirrhosis patients would complicate the esophagus varicosity(Esophageal varices, EV). Primary prophylaxis: non-selective β-blockers are used for the moderate to serious esophageal varices. However, ligation of portal vein may be performed for the patients with contraindication to β-blockers. Suspected varices bleeding is treated with vasoactivators, which including vasopressin and somatostatin. Vasopressin analogues include vasopressin(Pitressin)and terlipressin(Glypressin); somatostatin analogues include octreotide(Sandostatin)and somatostatin(Stilamin). Secondary prophylaxis: 50% of the patients with esophageal varices would have rebleeding. Those untreated patients with esophageal varices had the highest rate of rebleeding. We could combine nonselective β-blockers and nitrates for further treatment to decrease the incidence of rebleeding to 30%. |
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