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題 名 | Phosphodiesterase 5 Inhibitors Attenuate Renal Tubular Apoptosis after Partial Unilateral Ureteral Obstruction : An Experimental Study |
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作 者 | Akgül, Turgay; Huri, Emre; Yagmurdur, Hatice; Ayyıldız, Ali; Üstün, Hüseyin; Germiyanoğlu, Cankon; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 27:1 2011.01[民100.01] |
頁 次 | 頁15-19 |
分類號 | 415.74 |
關鍵詞 | Apoptosis; Partial ureteral obstruction; Sildenafil; Tadalafil; Vardenafil; |
語 文 | 英文(English) |
英文摘要 | The aim of the present study was to evaluate the effects of phosphodiesterase inhibitors on renal tubular apoptosis and also on expressions of endothelial and inducible nitric oxide synthases (eNOS and iNOS) in the ipsilateral kidney after partial unilateral ureteral obstruction (PUUO) in rat model. Forty Wistar albino rats were divided into five groups. In Groups 1e4, left experimental PUUO was created. Sildenafil, vardenafil, and tadalafil were administrated to the rats of Groups 2e4, respectively. The pills were orally given to the rats for 30 days. Group was defined as sham. After 30 days, all rats were sacrificed, and nephrec tomy was performed. The renal specimens were examined histopathologically. Left hydroure teronephrosis was observed in Groups 1e4. Mean apoptotic cell count and eNOS and iNOS levels were significantly increased in Group when compared with the other groups. The rats in Groups 2e4 showed significantly decreased apoptotic cell count and eNOS and iNOS values in the renal tubular tissue in accordance with Group (0.05). There were significant differ ences in apoptotic cell counts between sildenafil group and the other two study groups. The sildenafil group demonstrated lesser apoptotic cell count than the vardenafil (0.021) and tadalafil (0.009) groups. PUUO increases the renal tubular apoptosis and elevates NOS concentrations in renal tubular tissue after PUUO. Phosphodiesterase inhibitors have a protective effect against the tubular apoptosis. protective effect against the tubular apoptosis. |
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