頁籤選單縮合
題 名 | Atrichia with Papular Lesions in a Taiwanese Patient without Hairless (HR) Gene Mutation |
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作 者 | Lin, Hung-chien; Lee, Julia Yu-yun; Lin, Jeng-hsien; Chao, Sheau-chiou; | 書刊名 | Dermatologica Sinica |
卷 期 | 28:1 2010.03[民99.03] |
頁 次 | 頁40-43 |
分類號 | 415.66 |
關鍵詞 | Atrichia with papular lesions; HR gene; Taiwanese; |
語 文 | 英文(English) |
英文摘要 | Atrichia with papular lesions is a rare form of hair loss with an autosomal recessive mode of inheritance characterized by the absence of normal hair follicles and formation of intradermal cystic structures. Mutations in the hairless (HR) gene in both mice and human have been implicated in the development of this phenotype. HR codes for a putative transcription factor containing a single zinc-finger DNA binding domain, with restricted expression in the brain and the skin. Here, we report the first case of atrichia with papular lesions in a Taiwanese family with no detectable mutation in HR. |
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