頁籤選單縮合
題 名 | 中藥劑量與毒性間之關係探討及中藥肝腎毒性相關研究=Investigation of the Relationship between Dosage and Toxicity and the Hepatoxicity and Renal Toxicity Induced by Chinese Herb |
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作 者 | 陳玉芳; | 書刊名 | 中醫藥年報 |
卷 期 | 28:6 2010.09[民99.09] |
頁 次 | 頁285-328 |
分類號 | 414.32 |
關鍵詞 | |
語 文 | 中文(Chinese) |
中文摘要 | 研究背景與目的: 行政院衛生署中醫藥委員會為維護國人中藥用藥之安全,已推行了數年與中藥用藥安全之相關計畫,從中藥鑑定、誤混用、包裝、毒性,以至於中西藥之增效減毒/增毒、用藥安全宣導及中藥典之編撰;在在顯示政府機關及國人已逐漸重視到中藥之運用及對其安全性之必要規範。行政院衛生署中醫藥委員會曾於民國90至92年設立研究重點項目『中藥炮製前後成分鑑別、毒理、藥理文獻彙整』進行了地黃、大黃、附子、黃芩、半夏、杏仁等炮製前後之成分鑑別及毒性研究;雷公藤(Tripterygium wilfordii Hook.)為衛矛科雷公藤屬多年生長之藤本植物植物的乾燥根及根莖,由於其有效成分可能是中毒成分,安全範圍小,因此如何安全使用雷公藤,需進一步之探討及研究。而本計畫針對藥材之入藥部位不同對於用藥安全上之考量,針對雷公藤 進行其地上部、地下部去皮與不去皮(根及根皮)萃取物毒性與劑量關係及肝腎毒性之研究。 研究材料與方法: 雷公藤多生長於背陰、多濕稍肥的山坡山谷、溪邊濃木林及次生雜木林中。在臺灣分布於基隆金瓜石、台北縣石碇或台北市內湖一帶的海岸或山坡。雷公藤之採集可於基隆金瓜石、台北縣石碇山坡進行野外採集,本研究團隊分別於98年初春及夏末於南投縣仁愛鄉及台北縣石碇山坡採集得鮮品,經植物組織切片鑑定確認基原正確後使用,依不同步位進行急性毒性試驗與連續28天給藥之劑量與毒性探討。 結果與討論: 本計畫首先進行雷公藤之急性毒性試驗,結果發現,不同季節所採收之雷公藤,其毒性差異很大。如初春所採得之雷公藤,其莖與葉之LD50大於10g/kg,幾乎無毒;而夏末所採得之雷公藤,依其部位不同,其毒性也不相同,地上部(莖)之LD50=3.53g/kg,葉之LD50=5.06g/kg;地下部去皮(根)之 LD50=3.95g/kg,地下部之根皮LD50=1.67g/kg;大陸市售雷公藤之LD50大於10g/kg。各部位以subleather dose投予後,進行其肝、腎毒性之評估,結果均未發現肝腎有明顯之病變。而連續給藥28天,實驗結束後,觀察劑量與動物毒性之反應,包括血液學檢查、血液生化檢查、尿液檢查並進行病理檢查等,以了解雷公藤地上部(莖)、地下部去皮(根)與根皮萃取物之劑量與毒性及其對肝腎之影響。 |
英文摘要 | Research background and purpose: In order to protect the use safety of Chinese Herbal drug, CCMP of DOH has set up several research projects regarding to the policy of the use safety of Chinese Herbal drug. Many efforts have been done by the CCMP, including the identification, misuse, package, toxicity to the attenuation and synergism of toxicity between the combination of modern medicine and Chinese herbal drug, announcement of the use safety of Chinese Herbal drug and the compilation of Chinese herb pharmacopedia. According to the policy of the use safety of Chinese Herbal drug by CCMP, the relationship between dose and toxicity and hepatotoxicity and renal toxicity of Tripterygium wilfordii Hook (TW) was evaluated in this study. Material and Methods: TW was sampling in early spring and late summer from the mountain area of Jen-Ai township, Nan-tou County and Shih-Ding township, Taipei County. After the identification of plant origin, the acute toxicity and LD50 will be examined. Blood routine check, clinical biochemistry check, urine check, anatomy and pathological histological check will be primarily studied. Biochemical data check, pathological check will be used to evaluate the relationship between dose and toxicity and the hepatotoxicity, renal toxicity induced by Tripterygium wilfordii Hook. Results and Discussion: The toxicity of TW sampling in late summer was much more toxic than TW sampling in early spring. The acute toxicity of TW sampling in early spring is quite low, and the LD50 of several parts of TW (leaves, stem etc.) is greater than 10 g/kg. However, the acute toxicity of TW sampling from late summer is quite different. The LD50s of different parts of TW (leaves, stem, root and bark) are 5.06 g/kg, 3.53 g/kg, 3.95 g/lg and 1.67 g/kg, respectively. Plant sampling in different seasons made a difference in the acute toxicity of TW. The TW sample bought from China is less toxic, and its LD50 is more than 10 g/kg. Sub-leather dose of TW administration cause no significant change in both liver and kidney. |
本系統中英文摘要資訊取自各篇刊載內容。