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題名 | 維生素D受體基因多型性與牙周病之關連=The Relationship between Periodontitis and Vitamin D Receptor Gene Polymorphism--A Review |
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作者姓名(中文) | 陳涵鈺; 呂炫堃; | 書刊名 | 臺灣牙周病醫學會雜誌 |
卷期 | 15:3 2010.09[民99.09] |
頁次 | 頁215-230 |
分類號 | 416.946 |
關鍵詞 | 維生素D受體; 牙周病; 基因多型性; Vitamin D receptor; Periodontal disease; Gene polymorphism; |
語文 | 中文(Chinese) |
中文摘要 | 牙周病爲宿主免疫機制與細菌交互作用,進而破壞牙周組織的感染性疾病。而維生素D受體之基因多型性,與骨密度有關連,並影響到骨質疏鬆症、感染性疾病的發生,故維生素D受體基因適宜做爲牙周病易感性基因的研究對象。研究證實維生素D受體基因多型性變化與牙周病確實有顯著關連,但不同研究之結果卻時有差異。本文藉回顧過去文獻中,學者對於維生素D受體基因與牙周病易感性之相關研究,論述維生素D受體的生理功能,統整其基因多型性與牙周病之關聯,最後討論維生素D受體基因多型性如何對牙周病的易感性產生作用,並指出未來研究發展可能的方向。 |
英文摘要 | Periodontal disease is an infectious disease caused by the interaction of host immune and the bacteria and thus undermines the periodontal tissue. Since vitamin D plays a role in bone homeostasis and immune response, the receptor gene may associate with the susceptibility to periodontal disease. Previous experiments confirmed that the vitamin D receptor gene polymorphism and periodontal disease was significantly correlated, but there are still contradictory results in different studies. This article reviews the research of vitamin D receptor gene and susceptibility to periodontal disease, and to discuss the physiological function, its genetic polymorphism, and the effect of vitamin D receptor gene polymorphism to periodontal disease susceptibility. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。