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題名 | (1,3-Diphenyl-1H-pyrazol-4-yi)-methylamine Analogues as Inhibitors of Dipeptidyl Peptidases |
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作者 | 徐石; 陳炯東; 蔡廷岳; 鄭再宏; 伍素瑩; 張中年; 簡嘉慧; 葉凱嘉; 黃瑜雯; 黃貞龍; 黃中瑜; 吳思慧; 姜義坤; 王敏先; 趙宇生; 陳新; 蔣維棠; | 書刊名 | Journal of the Chinese Chemical Society |
卷期 | 56:5 2009.10[民98.10] |
頁次 | 頁1048-1055 |
分類號 | 346 |
關鍵詞 | Dipeptidyl peptidase; Inhibitor; Pyrazole; Diabetes; |
語文 | 英文(English) |
英文摘要 | The new (pyrazol-4-yl)-methylamines 8–15 were synthesized; their inhibitory activities of dipeptidyl peptidase IV and related enzymes were determined. The representative compound 15h exhibited an anti-hyperglycemic effect in animal model. |
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