頁籤選單縮合
題名 | Correlation between Quadrant Specific Automatic Visual Field Defect and Retinal Nerve Fiber Layer Thickness as Measured by Scanning Laser Polarimetry in Patients with Primary Open Angle Glaucoma=在原發性隅角開放型青光眼的病人使用視神經分析儀(GDx)測量視網膜神經層厚度和自動視野偵測視野缺損的一致性的比較 |
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作者 | 張祐誠; 蔡榮坤; Chang, Yo-chen; Tsai, Rong-kung; |
期刊 | The Kaohsiung Journal of Medical Sciences |
出版日期 | 20080500 |
卷期 | 24:5 2008.05[民97.05] |
頁次 | 頁233-239 |
分類號 | 416.748 |
語文 | eng |
關鍵詞 | 自動視野機; 平均偏差值; 視網膜神經層; 視神經分析儀; Autoperimetry; Mean deviation; Retinal nerve fiber layer; Scanning laser polarimetry; GDx; |
中文摘要 | 本篇研究目的在探討每個象限用 Humphrey 自動視野機偵測出的視野缺損以及用視神經分析儀 (GDx) 偵測出的視網膜神經層厚度之間的一致性,並且比較 GDx 內建的亞洲人正常資料庫和我們自己的正常資料庫對視野缺損的一致性是否有差異。在一個配對年紀的研究當中,對照組包含了 240 個正常眼睛接受 GDx 檢查。在實驗組包含了 60 個罹患隅角開放型青光眼的眼睛同時接受自動視野檢查以及 GDx 檢查。首先我們比較對照組和實驗組之間四個 GDx 測量值的差異性。接下來我們將視野分成四個象限 (上側,下側,顳側及鼻側) 並且計算每一個象限的平均偏差 (MD) 值。之後依照兩個資料庫 (GDx 內建亞洲人資料庫以及我們自己建立的對照組資料庫) 決定視網膜神經層厚度的異常與否並和上側下側以及總視野的 MD 值檢驗兩種測量方法的一致性。使用我們自己的正常資料庫來判斷 GDx 偵測的視網膜神經層厚度的異常與否比 GDx 內建的亞洲人資料庫來的正確 (上側 p = 0.0473,下側 p = 0.0074,整體 p = 0.0011) 而且兩個資料庫之間的特異性並無統計學上的差異。我們認為 GDx 內建的亞洲人資料庫的視網膜神經層厚度的正常範圍過大。在使用我們自己的正常資料庫之後,視網膜神經層厚度和視野之間的一致性能顯著的改善,因此我們建議擁有 GDx 的醫院最好能建立自己的正常值資料庫。 |
英文摘要 | The purpose of this study was to correlate quadrant specific Humphrey visual field mean deviation (MD) with retinal nerve fiber layer (RNFL) thickness as measured by scanning laser polarimetry (GDx), and to determine whether there is a difference in the correlation with visual field defect between the Asian normative database provided by GDx (GDx database) and our native normative database (KMU database). In an age-matched study, a control group of 240 normal eyes underwent GDx. Another 60 eyes with visual field defect due to primary angle glaucoma underwent autoperimetry and GDx examination. First, we compared four GDx measurements between the control and study groups. Next, we divided the visual field into four quadrants (superior, inferior, temporal, nasal) and calculated the MD of each quadrant. We correlated the MD of superior, inferior and overall visual field with RNFL thickness judged by two databases (the GDx Asian internal normative database and the database from our control group). GDx detected abnormal RNFL thickness significantly more accurately when using the KMU database (p = 0.0473 for superior quadrant; p = 0.0074 for inferior quadrant; p = 0.0011 for average thickness) than when using the GDx database. There was no significant difference in the specificity between these two databases. The normal ranges in the GDx internal normative database for Asians are too wide. By using our own GDx normative database, the correlations with MD of autoperimetry were significantly improved. We suggest that every laboratory and clinic establish its own normative database of GDx in Asia. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。