頁籤選單縮合
題 名 | Significant Relationship between Serum High-sensitivity C-Reactive Protein, High-density Lipoprotein Cholesterol Levels and Children with Kawasaki Disease and Coronary Artery Lesions |
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作 者 | Ou, Chun-yen; Tseng, Yu-fang; Lee, Cheng-liang; Chiou, Yee-hsuan; Hsieh, Kai-sheng; | 書刊名 | Journal of the Formosan Medical Association |
卷 期 | 108:9 2009.09[民98.09] |
頁 次 | 頁719-724 |
分類號 | 417.515 |
關鍵詞 | C-reactive protein; Cholesterol HDL; Coronary artery disease; Kawasaki disease; |
語 文 | 英文(English) |
英文摘要 | Background/Purpose The aim of this study was to understand the association between Kawasaki disease (KD) in children and serum high-sensitivity C-reactive protein (hs-CRP), which is a sensitive indicator of inflammation, lipid profiles and coronary artery lesions. Methods Between July 2005 and December 2007, 119 children with KD at least 1 year after diagnosis were recruited. The children were classified into one of two groups: Group I comprised 55 children with KD and coronary aneurysms; Group 2 comprised 64 children with KD and normal coronary arteries. The relationship between hs-CRP concentration and high-density lipoprotein cholesterol (HDL-C) and the size of arterial lesions was investigated in Group I 1 year after onset of KD. Results Serum hs-CRP levels in Group I (mean, 0.251mg/dL) were significantly greater than those in Group II (mean, 0.162mg/dL; p = 0.011). However, plasma HDL-C levels in Group I (mean 42.51 mg/dL) were significantly lower than those in Group II (mean, 44.34 mg/dL; p = 0.037). In Group I, there was a positive association between hs-CRP and the size of coronary artery lesions (r = 0.672, p = 0.035), but no association between lipid profiles, including HDL-C, and coronary artery lesions (all p > 0.05). Conclusion Our results support the possibility of ongoing low-grade inflammation late after the acute phase of KD in children with coronary aneurysms. Serum hs-CRP and HDL-C levels are associated with coronary artery lesions in children with KD. |
本系統中英文摘要資訊取自各篇刊載內容。