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頁籤選單縮合
題名 | Ductal Carcinoma of the Submandibular Gland=頜下腺腺管炎 |
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作者姓名(中文) | 黃祥富; 陳一豪; 李錦輝; 陳文政; 廖俊達; | 書刊名 | 臺灣耳鼻喉頭頸外科雜誌 |
卷期 | 44:5 2009.09-10[民98.09-10] |
頁次 | 頁160-164 |
分類號 | 416.8 |
關鍵詞 | 頜下腺; 唾液腺腺管癌; 頸部淋巴廓清術; 同步放療化療; Submandibular gland; Salivary ductal carcinoma; Neck dissection; Concurrent chemoradiation therapy; |
語文 | 英文(English) |
中文摘要 | 唾液腺腺管癌(salivary ductal carcinoma, SDC)臨床上較罕見而且多發生於腮腺。文獻報告該腫瘤具侵犯性且預後多不好。頜下腺的SDC更為罕見且預後較位於腮腺者更差。本文報告一名73歲男性頜下腺腺管癌(pT2N2bM0, Stage IVA, AJCC 2002)患者。該病患腫瘤生長快速,病患於就診時已有多發淋巴結轉移,細針抽取細胞檢查(fine-needle aspiration cytology)下並無法診斷該腫瘤。該腫瘤於顯微鏡下可見腫瘤細胞排列呈篩狀排列(cribriform pattern)型態並且呈現特殊性的”comedo-necrosis”。該病患接受頜下腺腫瘤切除手術與治療性的頸部淋巴廓清術合併術後cisplatin為主的同步放療化療(CCRT),放射線治療劑量為6120 cGy/34次。該病患在治療後追蹤48個月並無疾病復發。目前對於SDC治療上並無共識。然而,在我們的患者,雖然是第四期,但在手術併輔助性的放療化療後,可達到長期的存活率及疾病控制。 |
英文摘要 | Salivary ductal carcinoma (SDC) is rare and most in the parotid gland. It was reported to be aggressive and with poor prognosis. SDCs of the submandibular gland are rarer and the prognosis was worse than that in the parotid gland. Here we report a 73-yearold male of SDC of submandibular gland (pT2N2bM0, stage IVA, AJCC 2002). The presentation of the malignancy was rapid growth of neck mass within 3 weeks. Multiple lymph nodes metastases were found at the time of diagnosis. The patient received excision of submandibular gland tumor with neck dissection followed by cisplatinbased concurrent chemoradiation therapy (CCRT). The radiation dose was 6120 cGy/34 fractions. Pre-operative work-ups were difficult to diagnose this disease including fineneedle aspiration cytology or imaging studies. The tumor under microscope showed cancer cells arranged in cribriform pattern with characteristic ”comedo-necrosis”. The patient was free of disease in a follow-up of 48 months. There was no consensus yet on the treatment of SDC. Nevertheless, satisfactory locoregional control was achieved after surgery and adjuvant CCRT in our patient. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。