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題 名 | Pre-labor Rupture of Membranes at Term in Patients with an Unfavorable Cervix: Active Versus Conservative Management |
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作 者 | Ayaz, Aqueela; Saeed, Shazia; Farooq, Mian Usman; Ahmad, Fayaz; Bahoo, Luqman Ali; Ahmad, Iftikhar; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷 期 | 47:2 2008.06[民97.06] |
頁 次 | 頁192-196 |
分類號 | 417.2832 |
關鍵詞 | Induction; Labor; Misoprostol; PROM; |
語 文 | 英文(English) |
英文摘要 | Objective: To compare the safety and efficacy of conservative management of pre-labor rupture of membranes (PROM) at term in patients with an unfavorable cervix, with active treatment using oral misoprostol. Materials and Methods: This quasi-experimental study was conducted between June 1, 2004 and November 30, 2004 at Bahawal Victoria Hospital, Bahawalpur, Pakistan. Eighty-four multigravid women (parity, <5) at≥37 weeks' gestation and with unfavorable cervices were divided equally between group S (study) and group C (conservative). Group S was given 50 μg of oral misoprostol every 4 hours for a maximum of four doses, while group C was managed conservatively. The intervals between PROM and significant uterine contractions and delivery, the mode of delivery, and maternal and fetal/neonatal complications were the main outcome measures. Results: The intervals between PROM and the onset of uterine contractions and delivery were lower in group S than group C (9.6 vs. 14.8 hours; p<0.001) and (11.6 vs. 17 hours; p<0.001), respectively. Fewer women delivered abdominally within 24 hours of PROM in group S than in group C (5% vs. 24%; p<0.05). Induction failure in group S was less than conservative management failure in group C (10% vs. 60%; p<0.001). The maternal complication rate was less in group S than in group C (7% vs. 14%; p>0.05), but the fetal/neonatal complication rate was similar in both groups (5%). Conclusion: Oral misoprostol (50μg) is safe and effective for cervical ripening and labor induction in patients with PROM and an unfavorable cervix. |
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