頁籤選單縮合
題 名 | The Mechanisms of Medically Refractory Temporal Lobe Epilepsy |
---|---|
作 者 | Chayasirisobhon, Sirichai; | 書刊名 | Acta Neurologica Taiwanica |
卷 期 | 18:3 2009.09[民98.09] |
頁 次 | 頁155-160 |
分類號 | 415.932 |
關鍵詞 | Temporal lobe epilepsy; Hippocampal sclerosis; Antiepileptic drugs; |
語 文 | 英文(English) |
英文摘要 | The mechanisms underlying the refractory temporal lobe epilepsy (TLE) are not well understood. Several explanations for refractory TLE are (1) an overexpression of P-glycoprotein (P-gp) encoded by multiple drug resistance 1 (MDR1) gene and other efflux transporters such as multidrug resistance protein (MRP) in the cerebrovascular endothelium in or around the region of the epileptic focus may lead to drug resistance in epilepsy; (2) the loss of antiepileptic drug sensitivity at certain target sites in the brain, including the sodium ion channel and the gamma aminobutyric acid (GABA)A receptor; and (3) seizures beget seizures by means of a cascade of events that include various types of neuronal damage, sprouting of neuronal axons and new synapse formations that establish aberrant glutamatergic synapses. TLE may be a progressive neurological disorder that requires early and effective treatment. Early recognition of refractory TLE and referral for epilepsy surgery may prevent years of unnecessary seizure activity and its consequences. |
本系統中英文摘要資訊取自各篇刊載內容。