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題名 | Expression of Androgen Receptor in Human Placentas from Normal and Preeclamptic Pregnancies |
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作者姓名(外文) | Hsu, Te-yao; Lan, Kuo-chung; Tsai, Chih-chang; Ou, Chi-yu; Cheng, Bi-hua; Tsai, Men-yin; Kang, Hong-yo; Tung, Yu-hsia; Wong, Yi-hush; Huang, Ko-en; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷期 | 48:3 2009.09[民98.09] |
頁次 | 頁262-267 |
分類號 | 417.344 |
關鍵詞 | Androgen receptors; Placenta; Preeclampsia; |
語文 | 英文(English) |
英文摘要 | Objective: To elucidate the expression of androgen receptor (AR) in human placenta from normal and preeclamptic (PE) pregnancies. Materials and Methods: This study was performed at the Division of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Academic Medical Center. Forty normal pregnant women at 37.0±0.89 weeks' gestation and 40 women with preeclampsia at 35.9±1.33 weeks' gestation were included in this study. Serum testosterone was measured before delivery. Immunochemical methodology was employed in formalinfixed, paraffin-embedded sections from the placentas of all subjects. AR expression was evaluated in placentas collected from 15 normal pregnant women and 12 PE women. Results: Women with preeclampsia had an elevated serum testosterone level (0.52±0.13 vs. 0.34±0.11 ng/mL; p<0.01). The expression of AR in both placentas was confirmed using immunohistochemistry and was primarily present in the nucleus and cytoplasm of syncytiotrophoblasts and stromal cells. There was a significant increase in AR mRNA expression in PE placentas compared with normal placentas. Conclusion: These data suggest that the increased AR expression may alter AR-mediated function on syncytiotrophoblasts and stromal cells in PE placentas, and be a possible mechanism for its association with preeclampsia. |
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