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題名 | 中藥黃連成份小柏鹼抗人類肝腫瘤細胞作用之研究=Studies on the Berberine from Chinese Herb Coptis for the Anti-human Hepatocellular Carcinoma Effects |
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作者 | 邱永偉; 趙佩玉; 葉兆斌; 丁韋仁; 黃俊銘; | 書刊名 | 中西整合醫學雜誌 |
卷期 | 11:1 2009.06[民98.06] |
頁次 | 頁1-7 |
分類號 | 414.5 |
關鍵詞 | 小柏鹼; 人類肝腫瘤細胞; 粒線體膜電位; Berberine; Human hepatocellular carcinoma; Mitochondrial membrane potential; |
語文 | 中文(Chinese) |
中文摘要 | 近年來已有發現許多天然物中存在許多具生物活性之分子,而且有些甚至具有防癌及抑制癌細胞生長之功效。本研究發現中藥黃連中的成分小柏鹼(50μM)可以造成人類肝腫瘤細胞株(HepG2)死亡,但對正常的人類肝臟細胞株(Chang liver)並無影響。人類肝腫瘤細胞株(HepG2)經過12及24小時處理也會活化Fas和粒線體膜電位(△ψm)的下降而造成細胞的死亡,因此小柏鹼抗人類肝腫瘤之作用可能經由抑制粒線體途徑而進行。 |
英文摘要 | Recent studies have provided strong evidence that many daily-consumed dietary compounds possess cancer-protective properties that might interrupt the carcinogenesis process. Berberine is a main component of coptis. We further demonstrated that berberine (50 μM) exhibited significant cytotoxicity in humen hepatocellular carcinoma HepG2 cells but is ineffective in Chang liver cells. After berberine-treatment to HepG2 cells, mitochondrial membrane potential (△ψm) were lost at 24 h and activation of Fas at 12 h were also. These result provided that potential of anti-hepatoma activity of berberine may be mediated through an inhibition of mitochondria pathway. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。