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題名 | 癲癇與動作障礙之間的模糊地帶=The Borderland between Epilepsy and Movement Disorders |
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作者 | 黃欽威; 黃文柱; Huang, Chin-wei; Hwang, Wen-juh; |
期刊 | Acta Neurologica Taiwanica |
出版日期 | 20090300 |
卷期 | 18:1 2009.03[民98.03] |
頁次 | 頁42-55 |
分類號 | 415.932 |
語文 | chi |
關鍵詞 | 癲癇發作; 陣發性動作障礙; Epileptic seizure; Paroxysmal movement disorders; |
中文摘要 | 癲癇發作的表現若以運動現象爲主且不伴隨意識障礙,則有時會與陣發性動作障礙混淆。反之,陣發性動作障礙因爲發作突然、不可預期,發作時間短暫,加上有些病人發作前有預感,對抗癲癇藥物有良好的反應而被誤以爲是癲癇。另外,有些研究報告指出癲癇與動作障礙常合併出現在家族中不同的成員或甚至同一個病人身上,使得這兩種情境的區分更加混淆。最近的一些研究也指出某些癲癇與陣發性動作障礙是因爲離子通道的病變所造成,這也代表他們可能有共通的病態生理機制及部分的重疊性。臨床上,一個品質良好的病史詢問,嘗試去誘發發作並觀察記錄,輔以腦波加錄影、多頻道睡眠記錄,及其他電生理學檢查,再配合規則的追蹤,對於區分癲癇與陣發性動作障礙是很重要的。 |
英文摘要 | Epileptic seizures presenting as motor phenomena without concomitant conscious change may be confused with one of the paroxysmal movement disorders. Conversely, the attack of paroxysmal movement disorders may be thought to be epileptic due to a number of factors, including its sudden, unpredictable, and transient nature, its response to anticonvulsants, and the premonitory sensations preceding attacks. The distinction between epilepsy and movement disorders is further confused by the reports that these two conditions frequently occur in the same families or even in the same patients. Recent studies show that a few epilepsy and paroxysmal movement disorders are "channelopathies", indicating that they may share some common pathophysiology and a possible "overlap". A good quality of history, a trial to reproduce the motor phenomena, the application of video-EEG, polysomnography, and other electrophysiological recordings, together with regular follow-up are important for differentiating these two conditions. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。