頁籤選單縮合
題名 | Autologous Serum Skin Test and Autologous Whole Blood Injections to Patients with Chronic Urticaria: A Retrospective Analysis=探討自體血清注射試驗及自體全血注射治療於慢性蕁麻疹病患中所扮演的角色:一個回顧性分析 |
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作者 | 曾德朋; 李婉若; 林聖山; 許浚翃; 楊弘旭; 王國憲; 蔡秀欣; 蔡宗憲; Tseng, Jonathan Te-peng; Lee, Woan-ruoh; Lin, Sheng-shan; Hsu, Chun-hung; Yang, Hung-hsu; Wang, Kuo-hsien; Tsai, Hsiou-hsin; Tsai, Tsung-hsien; |
期刊 | 中華皮膚科醫學雜誌 |
出版日期 | 20090300 |
卷期 | 27:1 2009.03[民98.03] |
頁次 | 頁27-36 |
分類號 | 415.636 |
語文 | eng |
關鍵詞 | 自體血清注射; 自體全血注射; 蕁麻疹; Chronic urticaria; Autologous serum skin test; Autologous whole blood injection; |
英文摘要 | Background: Chronic urticaria (CU) is defi ned as widespread short-lived (< 24 h) itching maculopapular skin lesions with or without angioedema for more than 6 weeks for which a predominant physical cause must be excluded. The autologous serum skin test (ASST) has been shown to result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and autologous whole blood (AWB) injection has been used as one of treatment modalities. Objective: To evaluate the relationship of a panel of laboratory examinations to the positivity of ASST and to evaluate the effi cacy of AWB injection in the treatment of ASST (+) and ASST (–) CU patients. Methods: A retrospective chart review was performed on CU patients who were subjected to ASST and received AWB injection therapy. We assessed the therapeutic effects of 8 weekly AWB injections in ASST (+) and ASST (–) CU patients by using urticaria activity score (UAS). Results: Thiry-seven patients were analysed. There was no signifi cant differences in number of patients, sex distribution, age, smoking vs. non-smoking, exacerbation of uricarial symptoms due to stress, and UAS between ASST (+) and ASST (–) CU patients at baseline. All patients presented normal complete blood count/differential count, and ANA. Anti-microsomal antibody was positive in 3/15 (20.0%) ASST (+) patients and in 2/22 (9.0%) ASST (–) patients (P = 0.6). The 8-week course of AWB injection was well tolerated. ASST (+) patients, but not ASST (–) patients, showed signifi cantly reduced CU activity. Conclusion: 8 of the 9 ASST (+) patients with CU responded to treatment with AWB injection. Only 2 of the 8 ASST (–) patients showed response to the treatment. Others were having no effects or exacerbation of the urticarial symptoms. Further studies utilizing larger number of patients, longer follow-up periods, and different amount of autologous serum injection may better defi ne the clinical effi cacy of autologous serum injection for the treatment of chronic urticaria with positive ASST. |
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