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相關文獻
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頁籤選單縮合
題名 | Neutrophil Apoptosis is Negatively Related to Its Glutathione Content in Clinically Benign Febrile Patients Admitted to Emergency Department=在臨床預後良好的急診發燒病患血中中性白血球凋亡與胞內麩氨基硫含量呈負相關 |
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作者姓名(中文) | 林健盛; 馮安寧; 萬國良; 許永和; | 書刊名 | 臺灣急診醫學會醫誌 |
卷期 | 7:4 民94.12 |
頁次 | 頁252-265 |
分類號 | 415.208 |
關鍵詞 | 發燒; 中性白血球; 凋亡; 麩氨基硫; Apoptosis; Emergency room; Fever; Glutathione; Neutrophil; |
語文 | 英文(English) |
中文摘要 | 研究目的:中性白血球是宿主個體抵抗病菌感染的一個重要防禦反應細胞,已有文獻証實其胞內氨基硫狀態與凋亡的多寡有關。然而,這種相關性在於急診發燒病患的情況,至今未曾被報告過。方法:篩選臨床預後良好的急診發燒病人,進入研究樣本,排除會影響中性白血球的相關個案〈如:糖尿病、肝硬化或尿毒症等〉。在半年的實驗階段中,最後有19位符合標準進入研究,發燒狀態時爲實驗組,兩週後退燒爲控制組。細胞凋亡由流式細胞儀與DNA片斷技術來偵測,而胞內麩氨基硫含量則用高性能色層分析儀來偵測,在相同個體,不同體溫下分別取得血中中性白血球進行分析。結果:與控制組比較起來,在實驗組有較明顯的中性白血球凋亡,並且血漿中性白血球胞內麩氨基硫含量與白血球凋亡多寡呈負相關。結論:在臨床預後良好的急診發燒病人,其血中中性白血球凋亡增加,並且此增加與胞內麩氨基硫含量呈負相關。 |
英文摘要 | Objective: Neutrophils play an important role as effectors of host defense against microbial infection, and cellular thiols status has been reported relating its apoptosis. However, the status of cellular thiols and apoptosis of neutrophils in febrile patients admitted to the emergency department (ED) has not been reported to date. Methods: Neutrophil apoptosis was determined by flow cytometry and DNA fragmentation assay, plasma, and intra-neutrophil levels of reduced (GSH) and oxidized (GSSG) glutathione in 19 febrile patients admitted to the ED (experimental (EXP)-status patients) and two weeks after fever subsided (control (CN)-status patients). Results: Neutrophil apoptosis was significantly enhanced (P<0.05), and plasma and intra-neutrophil content of GSH were significantly decreased for EXP-status patients compared to those for CN-status patients. In addition, the intra-neutrophil content of GSH correlated negatively with neutrophil apoptosis in EXP-status patients. Conclusions: Neutrophil apoptosis was enhanced in clinically benign febrile patients admitted to the ED, and the enhancement of neutrophil apoptosis was correlated negatively with intra-neutrophil content of GSH. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。